HCSGD entry for CDH1

1. General information

Official gene symbolCDH1
Entrez ID999
Gene full namecadherin 1, type 1, E-cadherin (epithelial)
Other gene symbolsArc-1 CD324 CDHE ECAD LCAM UVO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0003382Epithelial cell morphogenesisIEAbiological_process
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005802Trans-Golgi networkIMPcellular_component
GO:0005886Plasma membraneIDA IEA TAScellular_component
GO:0005913Cell-cell adherens junctionIDAcellular_component
GO:0005925Focal adhesionIDAcellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006921Cellular component disassembly involved in execution phase of apoptosisTASbiological_process
GO:0007156Homophilic cell adhesionIEA NASbiological_process
GO:0007416Synapse assemblyIEAbiological_process
GO:0007605Sensory perception of soundIEAbiological_process
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009898Cytoplasmic side of plasma membraneIDAcellular_component
GO:0009986Cell surfaceIEAcellular_component
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDA IEAcellular_component
GO:0016235AggresomeIDAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016328Lateral plasma membraneIDAcellular_component
GO:0016337Cell-cell adhesionIDAbiological_process
GO:0016342Catenin complexIDAcellular_component
GO:0019538Protein metabolic processIEAbiological_process
GO:0019903Protein phosphatase bindingIEAmolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0022408Negative regulation of cell-cell adhesionIMPbiological_process
GO:0030054Cell junctionIDA TAScellular_component
GO:0030506Ankyrin bindingIPImolecular_function
GO:0031175Neuron projection developmentIEAbiological_process
GO:0032794GTPase activating protein bindingIPImolecular_function
GO:0033268Node of RanvierIEAcellular_component
GO:0033561Regulation of water loss via skinIEAbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0034332Adherens junction organizationTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042993Positive regulation of transcription factor import into nucleusIDAbiological_process
GO:0043219Lateral loopIEAcellular_component
GO:0043220Schmidt-Lanterman incisureIEAcellular_component
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043296Apical junction complexIDAcellular_component
GO:0043679Axon terminusIEAcellular_component
GO:0045177Apical part of cellIEAcellular_component
GO:0045216Cell-cell junction organizationTASbiological_process
GO:0045295Gamma-catenin bindingIPImolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050839Cell adhesion molecule bindingNASmolecular_function
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0060576Intestinal epithelial cell developmentIEAbiological_process
GO:0060662Salivary gland cavitationIEAbiological_process
GO:0060693Regulation of branching involved in salivary gland morphogenesisIEAbiological_process
GO:0070830Tight junction assemblyIEAbiological_process
GO:0071230Cellular response to amino acid stimulusIEAbiological_process
GO:0071285Cellular response to lithium ionIDAbiological_process
GO:0071681Cellular response to indole-3-methanolIDAbiological_process
GO:0072659Protein localization to plasma membraneIDAbiological_process
GO:0090090Negative regulation of canonical Wnt signaling pathwayIEAbiological_process
GO:0090102Cochlea developmentIEAbiological_process
GO:2000008Regulation of protein localization to cell surfaceIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.30485040460.77824076590.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0728937177
GSE13712_SHEARUp0.0113901994
GSE13712_STATICUp0.1477276072
GSE19018Up0.0679068534
GSE19899_A1Up0.1392586651
GSE19899_A2Down-0.0398599811
PubMed_21979375_A1Down-0.0802211428
PubMed_21979375_A2Up0.0534009604
GSE35957Up1.6060161083
GSE36640Up0.0708082218
GSE54402Up0.0454226469
GSE9593Down-0.0735092162
GSE43922Up0.0332200206
GSE24585Up0.3086554119
GSE37065Down-0.1337581036
GSE28863_A1Down-0.4407933164
GSE28863_A2Down-0.0800861450
GSE28863_A3Up0.1566272424
GSE28863_A4Up0.0523468922
GSE48662Down-0.1600583239

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-9-5pMIMAT0000441MIRT000029Western blotFunctional MTI19572217
hsa-miR-9-5pMIMAT0000441MIRT000029Reporter assay;Western blotFunctional MTI20173740
hsa-miR-25-3pMIMAT0000081MIRT006230Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22450326
hsa-miR-193b-3pMIMAT0002819MIRT016469ProteomicsFunctional MTI (Weak)21512034
hsa-miR-138-5pMIMAT0000430MIRT021686Western blotFunctional MTI21770894
hsa-miR-26b-5pMIMAT0000083MIRT029643MicroarrayFunctional MTI (Weak)19088304
hsa-miR-30c-5pMIMAT0000244MIRT047874CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21241890Here we show that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1, and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex
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