To systematically research the mechanism of cellular senescence, we construct the Human Cellular Senescence Gene Database (HCSGD) to integrate six types of senescence-associated information about human into one unified platform, including literature mining identified cellular senescence-associated genes and gene interactions from PubMed literature abstracts, the protein-protein interaction network from HPRD, high-throughput gene and microRNA expression profiling data from GEO, gene ontology annotations and information about which genes could be targeted by miRNAs (miRTarBase and miRecords), drugs (DRUGBANK) or compounds (ChEMBL). HCSGD provides comprehensive gene annotations, results of integrative meta-analysis and convenient links to other databases. We hope it could help you to retrieve information about cellular senescence in an easier manner and understand this important mechanism better.

Cellular senescence is an irreversible cell cycle arrest program that prevents the propagation of damaged cells at risk of malignant transformation. It has also been found to be closely related to tissue-repair, organismal aging and age-related degenerative diseases.