HCSGD entry for CDH1

1. General information

Official gene symbol	CDH1
Entrez ID	999
Gene full name	cadherin 1, type 1, E-cadherin (epithelial)
Other gene symbols	Arc-1 CD324 CDHE ECAD LCAM UVO
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0001829	Trophectodermal cell differentiation	IEA	biological_process
GO:0003382	Epithelial cell morphogenesis	IEA	biological_process
GO:0005509	Calcium ion binding	IEA	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005768	Endosome	IEA	cellular_component
GO:0005794	Golgi apparatus	IEA	cellular_component
GO:0005802	Trans-Golgi network	IMP	cellular_component
GO:0005886	Plasma membrane	IDA IEA TAS	cellular_component
GO:0005913	Cell-cell adherens junction	IDA	cellular_component
GO:0005925	Focal adhesion	IDA	cellular_component
GO:0006915	Apoptotic process	TAS	biological_process
GO:0006921	Cellular component disassembly involved in execution phase of apoptosis	TAS	biological_process
GO:0007156	Homophilic cell adhesion	IEA NAS	biological_process
GO:0007416	Synapse assembly	IEA	biological_process
GO:0007605	Sensory perception of sound	IEA	biological_process
GO:0008013	Beta-catenin binding	IDA	molecular_function
GO:0009636	Response to toxic substance	IEA	biological_process
GO:0009898	Cytoplasmic side of plasma membrane	IDA	cellular_component
GO:0009986	Cell surface	IEA	cellular_component
GO:0015629	Actin cytoskeleton	IDA	cellular_component
GO:0016020	Membrane	IEA	cellular_component
GO:0016021	Integral component of membrane	IDA IEA	cellular_component
GO:0016235	Aggresome	IDA	cellular_component
GO:0016323	Basolateral plasma membrane	IEA	cellular_component
GO:0016328	Lateral plasma membrane	IDA	cellular_component
GO:0016337	Cell-cell adhesion	IDA	biological_process
GO:0016342	Catenin complex	IDA	cellular_component
GO:0019538	Protein metabolic process	IEA	biological_process
GO:0019903	Protein phosphatase binding	IEA	molecular_function
GO:0019904	Protein domain specific binding	IEA	molecular_function
GO:0021983	Pituitary gland development	IEA	biological_process
GO:0022408	Negative regulation of cell-cell adhesion	IMP	biological_process
GO:0030054	Cell junction	IDA TAS	cellular_component
GO:0030506	Ankyrin binding	IPI	molecular_function
GO:0031175	Neuron projection development	IEA	biological_process
GO:0032794	GTPase activating protein binding	IPI	molecular_function
GO:0033268	Node of Ranvier	IEA	cellular_component
GO:0033561	Regulation of water loss via skin	IEA	biological_process
GO:0034329	Cell junction assembly	TAS	biological_process
GO:0034332	Adherens junction organization	TAS	biological_process
GO:0042493	Response to drug	IEA	biological_process
GO:0042993	Positive regulation of transcription factor import into nucleus	IDA	biological_process
GO:0043219	Lateral loop	IEA	cellular_component
GO:0043220	Schmidt-Lanterman incisure	IEA	cellular_component
GO:0043281	Regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA	biological_process
GO:0043296	Apical junction complex	IDA	cellular_component
GO:0043679	Axon terminus	IEA	cellular_component
GO:0045177	Apical part of cell	IEA	cellular_component
GO:0045216	Cell-cell junction organization	TAS	biological_process
GO:0045295	Gamma-catenin binding	IPI	molecular_function
GO:0045893	Positive regulation of transcription, DNA-templated	IDA	biological_process
GO:0048471	Perinuclear region of cytoplasm	IDA	cellular_component
GO:0050680	Negative regulation of epithelial cell proliferation	IEA	biological_process
GO:0050776	Regulation of immune response	TAS	biological_process
GO:0050839	Cell adhesion molecule binding	NAS	molecular_function
GO:0051260	Protein homooligomerization	IEA	biological_process
GO:0060576	Intestinal epithelial cell development	IEA	biological_process
GO:0060662	Salivary gland cavitation	IEA	biological_process
GO:0060693	Regulation of branching involved in salivary gland morphogenesis	IEA	biological_process
GO:0070830	Tight junction assembly	IEA	biological_process
GO:0071230	Cellular response to amino acid stimulus	IEA	biological_process
GO:0071285	Cellular response to lithium ion	IDA	biological_process
GO:0071681	Cellular response to indole-3-methanol	IDA	biological_process
GO:0072659	Protein localization to plasma membrane	IDA	biological_process
GO:0090090	Negative regulation of canonical Wnt signaling pathway	IEA	biological_process
GO:0090102	Cochlea development	IEA	biological_process
GO:2000008	Regulation of protein localization to cell surface	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.3048504046	0.7782407659	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.0728937177
GSE13712_SHEAR	Up	0.0113901994
GSE13712_STATIC	Up	0.1477276072
GSE19018	Up	0.0679068534
GSE19899_A1	Up	0.1392586651
GSE19899_A2	Down	-0.0398599811
PubMed_21979375_A1	Down	-0.0802211428
PubMed_21979375_A2	Up	0.0534009604
GSE35957	Up	1.6060161083
GSE36640	Up	0.0708082218
GSE54402	Up	0.0454226469
GSE9593	Down	-0.0735092162
GSE43922	Up	0.0332200206
GSE24585	Up	0.3086554119
GSE37065	Down	-0.1337581036
GSE28863_A1	Down	-0.4407933164
GSE28863_A2	Down	-0.0800861450
GSE28863_A3	Up	0.1566272424
GSE28863_A4	Up	0.0523468922
GSE48662	Down	-0.1600583239

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

MiRNA_name	mirBase ID	miRTarBase ID	Experiment	Support type	References (Pubmed ID)
hsa-miR-9-5p	MIMAT0000441	MIRT000029	Western blot	Functional MTI	19572217
hsa-miR-9-5p	MIMAT0000441	MIRT000029	Reporter assay;Western blot	Functional MTI	20173740
hsa-miR-25-3p	MIMAT0000081	MIRT006230	Luciferase reporter assay//qRT-PCR//Western blot	Functional MTI	22450326
hsa-miR-193b-3p	MIMAT0002819	MIRT016469	Proteomics	Functional MTI (Weak)	21512034
hsa-miR-138-5p	MIMAT0000430	MIRT021686	Western blot	Functional MTI	21770894
hsa-miR-26b-5p	MIMAT0000083	MIRT029643	Microarray	Functional MTI (Weak)	19088304
hsa-miR-30c-5p	MIMAT0000244	MIRT047874	CLASH	Functional MTI (Weak)	23622248

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mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.

PubMed ID of the article	Sentenece the gene occurs
21241890	Here we show that nuclear PTEN interacts with APC/C, promotes APC/C association with CDH1, and thereby enhances the tumor-suppressive activity of the APC-CDH1 complex

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Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for CDH1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

MicroRNAs

mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.

PubMed ID of the article

Sentenece the gene occurs

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )