HCSGD entry for CDC27

1. General information

Official gene symbolCDC27
Entrez ID996
Gene full namecell division cycle 27
Other gene symbolsANAPC3 APC3 CDC27Hs D0S1430E D17S978E HNUC NUC2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000278Mitotic cell cycleTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005680Anaphase-promoting complexIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005819SpindleTAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005876Spindle microtubuleIDAcellular_component
GO:0007091Metaphase/anaphase transition of mitotic cell cycleIMPbiological_process
GO:0007094Mitotic spindle assembly checkpointTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0051301Cell divisionIEAbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0070979Protein K11-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45687280880.54308474600.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1313372643
GSE13712_SHEARUp0.3425309459
GSE13712_STATICUp0.0721551490
GSE19018Down-0.0104726415
GSE19899_A1Down-0.1828664268
GSE19899_A2Down-0.1963271599
PubMed_21979375_A1Up0.0955215305
PubMed_21979375_A2Down-0.0163755281
GSE35957Down-0.0117181626
GSE36640Down-0.2103166258
GSE54402Up0.2304892811
GSE9593Up0.1013575276
GSE43922Down-0.0419053567
GSE24585Up0.2792385257
GSE37065Up0.0592791279
GSE28863_A1Up0.0309292010
GSE28863_A2Up0.3546056249
GSE28863_A3Down-0.7016040129
GSE28863_A4Up0.2115301039
GSE48662Up0.0739624483

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022384Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-32-5pMIMAT0000090MIRT028274SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031584SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.