HCSGD entry for CDC27
1. General information
| Official gene symbol | CDC27 |
|---|---|
| Entrez ID | 996 |
| Gene full name | cell division cycle 27 |
| Other gene symbols | ANAPC3 APC3 CDC27Hs D0S1430E D17S978E HNUC NUC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005680 | Anaphase-promoting complex | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0005819 | Spindle | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005876 | Spindle microtubule | IDA | cellular_component |
| GO:0007091 | Metaphase/anaphase transition of mitotic cell cycle | IMP | biological_process |
| GO:0007094 | Mitotic spindle assembly checkpoint | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0031145 | Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | TAS | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0051436 | Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051437 | Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0051439 | Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | TAS | biological_process |
| GO:0070979 | Protein K11-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4568728088 | 0.5430847460 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1313372643 |
| GSE13712_SHEAR | Up | 0.3425309459 |
| GSE13712_STATIC | Up | 0.0721551490 |
| GSE19018 | Down | -0.0104726415 |
| GSE19899_A1 | Down | -0.1828664268 |
| GSE19899_A2 | Down | -0.1963271599 |
| PubMed_21979375_A1 | Up | 0.0955215305 |
| PubMed_21979375_A2 | Down | -0.0163755281 |
| GSE35957 | Down | -0.0117181626 |
| GSE36640 | Down | -0.2103166258 |
| GSE54402 | Up | 0.2304892811 |
| GSE9593 | Up | 0.1013575276 |
| GSE43922 | Down | -0.0419053567 |
| GSE24585 | Up | 0.2792385257 |
| GSE37065 | Up | 0.0592791279 |
| GSE28863_A1 | Up | 0.0309292010 |
| GSE28863_A2 | Up | 0.3546056249 |
| GSE28863_A3 | Down | -0.7016040129 |
| GSE28863_A4 | Up | 0.2115301039 |
| GSE48662 | Up | 0.0739624483 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022384 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028274 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031584 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
