HCSGD entry for KEAP1
1. General information
| Official gene symbol | KEAP1 |
|---|---|
| Entrez ID | 9817 |
| Gene full name | kelch-like ECH-associated protein 1 |
| Other gene symbols | INrf2 KLHL19 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IEA | cellular_component |
| GO:0005813 | Centrosome | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0010499 | Proteasomal ubiquitin-independent protein catabolic process | IDA | biological_process |
| GO:0016567 | Protein ubiquitination | IDA IEA | biological_process |
| GO:0030496 | Midbody | IDA | cellular_component |
| GO:0031463 | Cul3-RING ubiquitin ligase complex | IDA | cellular_component |
| GO:0045604 | Regulation of epidermal cell differentiation | IEA | biological_process |
| GO:0071353 | Cellular response to interleukin-4 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0329781695 | 0.9476545382 | 0.4186675481 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.7910099610 |
| GSE13712_SHEAR | Up | 0.0573049812 |
| GSE13712_STATIC | Up | 0.0783663528 |
| GSE19018 | Down | -0.2029367259 |
| GSE19899_A1 | Up | 0.4963800551 |
| GSE19899_A2 | Up | 0.7409168231 |
| PubMed_21979375_A1 | Up | 0.4234135983 |
| PubMed_21979375_A2 | Up | 1.1210573963 |
| GSE35957 | Down | -0.4396457375 |
| GSE36640 | Down | -0.1822007610 |
| GSE54402 | Up | 0.4265909409 |
| GSE9593 | Down | -0.0150078224 |
| GSE43922 | Up | 0.2993606523 |
| GSE24585 | Up | 0.0734426304 |
| GSE37065 | Up | 0.1502158786 |
| GSE28863_A1 | Up | 0.0764915833 |
| GSE28863_A2 | Down | -0.0791523137 |
| GSE28863_A3 | Down | -0.3271571883 |
| GSE28863_A4 | Up | 0.0735547080 |
| GSE48662 | Up | 0.0897771614 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-200a-3p | MIMAT0000682 | MIRT006704 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21914820 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025794 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029595 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040649 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26386875 | Methylene blue (MB) delays cellular senescence, induces complex-IV, and activates Keap1/Nrf2; however, the molecular link of these effects to MB is unclear |
| 26386875 | The current findings in conjunction with the activation of Keap1/Nrf2 suggest a synchronized activation of the energy and cellular defense pathways as a possible key factor in MB's potent anti-senescence activity |
| 23157314 | For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras |
| 23157314 | CRITICAL ISSUES: Site-specific S-guanylation of Keap1 at Cys434 induced NO- and ROS-mediated adaptive responses to oxidative stress |
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