HCSGD entry for KEAP1

1. General information

Official gene symbolKEAP1
Entrez ID9817
Gene full namekelch-like ECH-associated protein 1
Other gene symbolsINrf2 KLHL19
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001701In utero embryonic developmentIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0010499Proteasomal ubiquitin-independent protein catabolic processIDAbiological_process
GO:0016567Protein ubiquitinationIDA IEAbiological_process
GO:0030496MidbodyIDAcellular_component
GO:0031463Cul3-RING ubiquitin ligase complexIDAcellular_component
GO:0045604Regulation of epidermal cell differentiationIEAbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.03297816950.94765453820.41866754811.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7910099610
GSE13712_SHEARUp0.0573049812
GSE13712_STATICUp0.0783663528
GSE19018Down-0.2029367259
GSE19899_A1Up0.4963800551
GSE19899_A2Up0.7409168231
PubMed_21979375_A1Up0.4234135983
PubMed_21979375_A2Up1.1210573963
GSE35957Down-0.4396457375
GSE36640Down-0.1822007610
GSE54402Up0.4265909409
GSE9593Down-0.0150078224
GSE43922Up0.2993606523
GSE24585Up0.0734426304
GSE37065Up0.1502158786
GSE28863_A1Up0.0764915833
GSE28863_A2Down-0.0791523137
GSE28863_A3Down-0.3271571883
GSE28863_A4Up0.0735547080
GSE48662Up0.0897771614

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200a-3pMIMAT0000682MIRT006704Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI21914820
hsa-miR-7-5pMIMAT0000252MIRT025794SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT029595MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92b-3pMIMAT0003218MIRT040649CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26386875Methylene blue (MB) delays cellular senescence, induces complex-IV, and activates Keap1/Nrf2; however, the molecular link of these effects to MB is unclear
26386875The current findings in conjunction with the activation of Keap1/Nrf2 suggest a synchronized activation of the energy and cellular defense pathways as a possible key factor in MB's potent anti-senescence activity
23157314For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras
23157314CRITICAL ISSUES: Site-specific S-guanylation of Keap1 at Cys434 induced NO- and ROS-mediated adaptive responses to oxidative stress
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