HCSGD entry for RAPGEF5
1. General information
| Official gene symbol | RAPGEF5 |
|---|---|
| Entrez ID | 9771 |
| Gene full name | Rap guanine nucleotide exchange factor (GEF) 5 |
| Other gene symbols | GFR MR-GEF REPAC |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0007264 | Small GTPase mediated signal transduction | IEA NAS | biological_process |
| GO:0007399 | Nervous system development | NAS | biological_process |
| GO:0017034 | Rap guanyl-nucleotide exchange factor activity | IDA | molecular_function |
| GO:0030742 | GTP-dependent protein binding | IPI | molecular_function |
| GO:0032317 | Regulation of Rap GTPase activity | IDA | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | IDA TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | IDA TAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4812949204 | 0.7698763649 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0320335172 |
| GSE13712_SHEAR | Up | 0.0769317263 |
| GSE13712_STATIC | Up | 0.0186305970 |
| GSE19018 | Down | -0.0311460056 |
| GSE19899_A1 | Up | 0.1509534166 |
| GSE19899_A2 | Up | 0.0660990377 |
| PubMed_21979375_A1 | Up | 0.1370769472 |
| PubMed_21979375_A2 | Up | 0.1376776031 |
| GSE35957 | Up | 0.1827089674 |
| GSE36640 | Up | 0.0098660387 |
| GSE54402 | Up | 0.1342297224 |
| GSE9593 | Up | 0.0351905686 |
| GSE43922 | Up | 0.0115638150 |
| GSE24585 | Down | -0.6411060263 |
| GSE37065 | Up | 0.0174651533 |
| GSE28863_A1 | Down | -0.1284046350 |
| GSE28863_A2 | Up | 0.7052955374 |
| GSE28863_A3 | Up | 0.0203407288 |
| GSE28863_A4 | Up | 0.0250895756 |
| GSE48662 | Up | 0.0541033571 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 19797472 | Here, we found that the PPAR-gamma agonist pioglitazone protected against renal injury in aging; it reduced proteinuria, improved GFR, decreased sclerosis, and alleviated cell senescence |
| 9049488 | Diastolic blood pressure was also related to the rate of GFR change (r = 0 |
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