HCSGD entry for RAPGEF5

1. General information

Official gene symbolRAPGEF5
Entrez ID9771
Gene full nameRap guanine nucleotide exchange factor (GEF) 5
Other gene symbolsGFR MR-GEF REPAC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005085Guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005088Ras guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005622IntracellularIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0007264Small GTPase mediated signal transductionIEA NASbiological_process
GO:0007399Nervous system developmentNASbiological_process
GO:0017034Rap guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0030742GTP-dependent protein bindingIPImolecular_function
GO:0032317Regulation of Rap GTPase activityIDAbiological_process
GO:0032318Regulation of Ras GTPase activityIDA TASbiological_process
GO:0043087Regulation of GTPase activityIDA TASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48129492040.76987636490.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0320335172
GSE13712_SHEARUp0.0769317263
GSE13712_STATICUp0.0186305970
GSE19018Down-0.0311460056
GSE19899_A1Up0.1509534166
GSE19899_A2Up0.0660990377
PubMed_21979375_A1Up0.1370769472
PubMed_21979375_A2Up0.1376776031
GSE35957Up0.1827089674
GSE36640Up0.0098660387
GSE54402Up0.1342297224
GSE9593Up0.0351905686
GSE43922Up0.0115638150
GSE24585Down-0.6411060263
GSE37065Up0.0174651533
GSE28863_A1Down-0.1284046350
GSE28863_A2Up0.7052955374
GSE28863_A3Up0.0203407288
GSE28863_A4Up0.0250895756
GSE48662Up0.0541033571

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19797472Here, we found that the PPAR-gamma agonist pioglitazone protected against renal injury in aging; it reduced proteinuria, improved GFR, decreased sclerosis, and alleviated cell senescence
9049488Diastolic blood pressure was also related to the rate of GFR change (r = 0
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