HCSGD entry for SETD1A
1. General information
| Official gene symbol | SETD1A |
|---|---|
| Entrez ID | 9739 |
| Gene full name | SET domain containing 1A |
| Other gene symbols | KMT2F Set1 Set1A |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006479 | Protein methylation | IDA | biological_process |
| GO:0016571 | Histone methylation | IDA | biological_process |
| GO:0016607 | Nuclear speck | IEA | cellular_component |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0018024 | Histone-lysine N-methyltransferase activity | IEA | molecular_function |
| GO:0034968 | Histone lysine methylation | IDA | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5945866570 | 0.5185406216 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0292322066 |
| GSE13712_SHEAR | Down | -0.2735731513 |
| GSE13712_STATIC | Down | -0.2459567454 |
| GSE19018 | Down | -0.2780376189 |
| GSE19899_A1 | Down | -0.3062206483 |
| GSE19899_A2 | Up | 0.1382225707 |
| PubMed_21979375_A1 | Down | -0.0501956666 |
| PubMed_21979375_A2 | Up | 0.2109162578 |
| GSE35957 | Down | -0.3705571941 |
| GSE36640 | Down | -0.0371719504 |
| GSE54402 | Up | 0.0991978010 |
| GSE9593 | Up | 0.0022147126 |
| GSE43922 | Up | 0.1389566738 |
| GSE24585 | Down | -0.2068163863 |
| GSE37065 | Down | -0.0211862995 |
| GSE28863_A1 | Down | -0.0107342363 |
| GSE28863_A2 | Up | 0.1070266480 |
| GSE28863_A3 | Up | 0.4775670601 |
| GSE28863_A4 | Up | 0.0839163626 |
| GSE48662 | Up | 0.1479559524 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-760 | MIMAT0004957 | MIRT036712 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-3p | MIMAT0002891 | MIRT040819 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-361-5p | MIMAT0000703 | MIRT044067 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044797 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051709 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
