HCSGD entry for CD74

1. General information

Official gene symbolCD74
Entrez ID972
Gene full nameCD74 molecule, major histocompatibility complex, class II invariant chain
Other gene symbolsDHLAG HLADG II Ia-GAMMA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001516Prostaglandin biosynthetic processIDAbiological_process
GO:0001540Beta-amyloid bindingIPImolecular_function
GO:0001961Positive regulation of cytokine-mediated signaling pathwayIMPbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationIEAbiological_process
GO:0002792Negative regulation of peptide secretionIDAbiological_process
GO:0002830Positive regulation of type 2 immune responseIEAbiological_process
GO:0002906Negative regulation of mature B cell apoptotic processIEAbiological_process
GO:0004896Cytokine receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularTAScellular_component
GO:0005765Lysosomal membraneTAScellular_component
GO:0005771Multivesicular bodyIEAcellular_component
GO:0005773VacuoleIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006461Protein complex assemblyISSbiological_process
GO:0006886Intracellular protein transportIEA ISSbiological_process
GO:0006952Defense responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0016064Immunoglobulin mediated immune responseISSbiological_process
GO:0019882Antigen processing and presentationIEAbiological_process
GO:0019883Antigen processing and presentation of endogenous antigenNASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0019955Cytokine bindingIPImolecular_function
GO:0030658Transport vesicle membraneTAScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0032588Trans-Golgi network membraneTAScellular_component
GO:0035691Macrophage migration inhibitory factor signaling pathwayIEAbiological_process
GO:0035692Macrophage migration inhibitory factor receptor complexIDAcellular_component
GO:0035693NOS2-CD74 complexIEAcellular_component
GO:0035718Macrophage migration inhibitory factor bindingIPImolecular_function
GO:0042289MHC class II protein bindingIEA ISS NASmolecular_function
GO:0042613MHC class II protein complexISScellular_component
GO:0042802Identical protein bindingTASmolecular_function
GO:0043030Regulation of macrophage activationNASbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIDAbiological_process
GO:0045058T cell selectionNASbiological_process
GO:0045059Positive thymic T cell selectionIEAbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045581Negative regulation of T cell differentiationIEAbiological_process
GO:0045582Positive regulation of T cell differentiationIEAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050998Nitric-oxide synthase bindingIEAmolecular_function
GO:0051085Chaperone mediated protein folding requiring cofactorIEAbiological_process
GO:0060907Positive regulation of macrophage cytokine productionISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IMPbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:0090023Positive regulation of neutrophil chemotaxisISSbiological_process
GO:1902166Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMPbiological_process
GO:2000343Positive regulation of chemokine (C-X-C motif) ligand 2 productionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96245182550.28519286880.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0089655253
GSE13712_SHEARDown-0.0573539293
GSE13712_STATICDown-0.0321132157
GSE19018Up0.0547990367
GSE19899_A1Down-0.1527334559
GSE19899_A2Up0.0003798854
PubMed_21979375_A1Up0.1056574286
PubMed_21979375_A2Up0.0147380520
GSE35957Down-0.7048787941
GSE36640Down-0.0816867551
GSE54402Down-0.0614200184
GSE9593Up0.0919201651
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.3228476481

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.