HCSGD entry for CD74

1. General information

Official gene symbolCD74
Entrez ID972
Gene full nameCD74 molecule, major histocompatibility complex, class II invariant chain
Other gene symbolsDHLAG HLADG II Ia-GAMMA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneTAScellular_component
GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001516Prostaglandin biosynthetic processIDAbiological_process
GO:0001540Beta-amyloid bindingIPImolecular_function
GO:0001961Positive regulation of cytokine-mediated signaling pathwayIMPbiological_process
GO:0002606Positive regulation of dendritic cell antigen processing and presentationIEAbiological_process
GO:0002792Negative regulation of peptide secretionIDAbiological_process
GO:0002830Positive regulation of type 2 immune responseIEAbiological_process
GO:0002906Negative regulation of mature B cell apoptotic processIEAbiological_process
GO:0004896Cytokine receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularTAScellular_component
GO:0005765Lysosomal membraneTAScellular_component
GO:0005771Multivesicular bodyIEAcellular_component
GO:0005773VacuoleIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006461Protein complex assemblyISSbiological_process
GO:0006886Intracellular protein transportIEA ISSbiological_process
GO:0006952Defense responseIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008283Cell proliferationIDAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0012507ER to Golgi transport vesicle membraneTAScellular_component
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0016064Immunoglobulin mediated immune responseISSbiological_process
GO:0019882Antigen processing and presentationIEAbiological_process
GO:0019883Antigen processing and presentation of endogenous antigenNASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0019955Cytokine bindingIPImolecular_function
GO:0030658Transport vesicle membraneTAScellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0030669Clathrin-coated endocytic vesicle membraneTAScellular_component
GO:0030890Positive regulation of B cell proliferationIMPbiological_process
GO:0032588Trans-Golgi network membraneTAScellular_component
GO:0035691Macrophage migration inhibitory factor signaling pathwayIEAbiological_process
GO:0035692Macrophage migration inhibitory factor receptor complexIDAcellular_component
GO:0035693NOS2-CD74 complexIEAcellular_component
GO:0035718Macrophage migration inhibitory factor bindingIPImolecular_function
GO:0042289MHC class II protein bindingIEA ISS NASmolecular_function
GO:0042613MHC class II protein complexISScellular_component
GO:0042802Identical protein bindingTASmolecular_function
GO:0043030Regulation of macrophage activationNASbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0043518Negative regulation of DNA damage response, signal transduction by p53 class mediatorIDAbiological_process
GO:0045058T cell selectionNASbiological_process
GO:0045059Positive thymic T cell selectionIEAbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045581Negative regulation of T cell differentiationIEAbiological_process
GO:0045582Positive regulation of T cell differentiationIEAbiological_process
GO:0048146Positive regulation of fibroblast proliferationIMPbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050998Nitric-oxide synthase bindingIEAmolecular_function
GO:0051085Chaperone mediated protein folding requiring cofactorIEAbiological_process
GO:0060907Positive regulation of macrophage cytokine productionISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IMPbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:0090023Positive regulation of neutrophil chemotaxisISSbiological_process
GO:1902166Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorIMPbiological_process
GO:2000343Positive regulation of chemokine (C-X-C motif) ligand 2 productionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96245182550.28519286880.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0089655253
GSE13712_SHEARDown-0.0573539293
GSE13712_STATICDown-0.0321132157
GSE19018Up0.0547990367
GSE19899_A1Down-0.1527334559
GSE19899_A2Up0.0003798854
PubMed_21979375_A1Up0.1056574286
PubMed_21979375_A2Up0.0147380520
GSE35957Down-0.7048787941
GSE36640Down-0.0816867551
GSE54402Down-0.0614200184
GSE9593Up0.0919201651
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-0.3228476481

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.