HCSGD entry for NR1D1

1. General information

Official gene symbolNR1D1
Entrez ID9572
Gene full namenuclear receptor subfamily 1, group D, member 1
Other gene symbolsEAR1 THRA1 THRAL ear-1 hRev
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001222Transcription corepressor bindingIDA IMPmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmISScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0010498Proteasomal protein catabolic processISSbiological_process
GO:0010871Negative regulation of receptor biosynthetic processIMPbiological_process
GO:0019216Regulation of lipid metabolic processISSbiological_process
GO:0020037Heme bindingIDAmolecular_function
GO:0030154Cell differentiationIEAbiological_process
GO:0030425DendriteISScellular_component
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0034144Negative regulation of toll-like receptor 4 signaling pathwayIMPbiological_process
GO:0035947Regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoterIMPbiological_process
GO:0042752Regulation of circadian rhythmISSbiological_process
GO:0043197Dendritic spineISScellular_component
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0044321Response to leptinISSbiological_process
GO:0045598Regulation of fat cell differentiationISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0060086Circadian temperature homeostasisISSbiological_process
GO:0061178Regulation of insulin secretion involved in cellular response to glucose stimulusISSbiological_process
GO:0061469Regulation of type B pancreatic cell proliferationISSbiological_process
GO:0070859Positive regulation of bile acid biosynthetic processISSbiological_process
GO:0071222Cellular response to lipopolysaccharideIMPbiological_process
GO:2000188Regulation of cholesterol homeostasisISSbiological_process
GO:2000189Positive regulation of cholesterol homeostasisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08971289080.96695974320.62918545161.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up0.5159286452
GSE24585Down-0.1147909205
GSE37065Up0.5150224631
GSE28863_A1Up0.1640519229
GSE28863_A2Up0.2486199954
GSE28863_A3Up0.6015038451
GSE28863_A4Down-0.1350410352
GSE48662Up0.0511486129

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017335MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.