HCSGD entry for PSMF1

1. General information

Official gene symbolPSMF1
Entrez ID9491
Gene full nameproteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Other gene symbolsPI31
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004866Endopeptidase inhibitor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexNAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processNASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010466Negative regulation of peptidase activityNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010951Negative regulation of endopeptidase activityNASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0052547Regulation of peptidase activityNASbiological_process
GO:0052548Regulation of endopeptidase activityNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32337076860.93505086050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0395318781
GSE13712_SHEARUp0.1588273081
GSE13712_STATICUp0.2566671752
GSE19018Down-0.0385305976
GSE19899_A1Up0.0393040283
GSE19899_A2Up0.4197971906
PubMed_21979375_A1Up0.3375927411
PubMed_21979375_A2Up0.3942922981
GSE35957Down-0.0258314184
GSE36640Down-0.1101287612
GSE54402Down-0.2339123911
GSE9593Up0.1270614880
GSE43922Up0.0646156018
GSE24585Up0.1051755670
GSE37065Down-0.0430138127
GSE28863_A1Up0.2566289594
GSE28863_A2Up0.0710046407
GSE28863_A3Down-0.0002592341
GSE28863_A4Down-0.0107065180
GSE48662Down-0.0187585033

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT039672CLASHFunctional MTI (Weak)23622248
hsa-miR-151a-3pMIMAT0000757MIRT043618CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044684CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049749CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.