HCSGD entry for PSMF1

1. General information

Official gene symbolPSMF1
Entrez ID9491
Gene full nameproteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Other gene symbolsPI31
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004866Endopeptidase inhibitor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005839Proteasome core complexNAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processNASbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010466Negative regulation of peptidase activityNASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010951Negative regulation of endopeptidase activityNASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051436Negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0052547Regulation of peptidase activityNASbiological_process
GO:0052548Regulation of endopeptidase activityNASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32337076860.93505086050.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0395318781
GSE13712_SHEARUp0.1588273081
GSE13712_STATICUp0.2566671752
GSE19018Down-0.0385305976
GSE19899_A1Up0.0393040283
GSE19899_A2Up0.4197971906
PubMed_21979375_A1Up0.3375927411
PubMed_21979375_A2Up0.3942922981
GSE35957Down-0.0258314184
GSE36640Down-0.1101287612
GSE54402Down-0.2339123911
GSE9593Up0.1270614880
GSE43922Up0.0646156018
GSE24585Up0.1051755670
GSE37065Down-0.0430138127
GSE28863_A1Up0.2566289594
GSE28863_A2Up0.0710046407
GSE28863_A3Down-0.0002592341
GSE28863_A4Down-0.0107065180
GSE48662Down-0.0187585033

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT039672CLASHFunctional MTI (Weak)23622248
hsa-miR-151a-3pMIMAT0000757MIRT043618CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044684CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049749CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.