HCSGD entry for SCARB1

1. General information

Official gene symbolSCARB1
Entrez ID949
Gene full namescavenger receptor class B, member 1
Other gene symbolsCD36L1 CLA-1 CLA1 HDLQTL6 SR-BI SRB1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001530Lipopolysaccharide bindingIDAmolecular_function
GO:0001786Phosphatidylserine bindingISSmolecular_function
GO:0001875Lipopolysaccharide receptor activityIDAmolecular_function
GO:0001935Endothelial cell proliferationIEAbiological_process
GO:0002221Pattern recognition receptor signaling pathwayIDAbiological_process
GO:0005215Transporter activityTASmolecular_function
GO:00055451-phosphatidylinositol bindingTASmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0005901CaveolaTAScellular_component
GO:0006702Androgen biosynthetic processIEAbiological_process
GO:0006707Cholesterol catabolic processIEAbiological_process
GO:0006898Receptor-mediated endocytosisIDAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008035High-density lipoprotein particle bindingIEAmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0010595Positive regulation of endothelial cell migrationTASbiological_process
GO:0010867Positive regulation of triglyceride biosynthetic processISSbiological_process
GO:0010886Positive regulation of cholesterol storageIDAbiological_process
GO:0010899Regulation of phosphatidylcholine catabolic processISSbiological_process
GO:0015914Phospholipid transportISSbiological_process
GO:0015920Lipopolysaccharide transportIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0030169Low-density lipoprotein particle bindingIDAmolecular_function
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0031528Microvillus membraneIEAcellular_component
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0032497Detection of lipopolysaccharideIDAbiological_process
GO:0033344Cholesterol effluxISSbiological_process
GO:0034185Apolipoprotein bindingIPImolecular_function
GO:0034186Apolipoprotein A-I bindingIPImolecular_function
GO:0034375High-density lipoprotein particle remodelingISSbiological_process
GO:0034383Low-density lipoprotein particle clearanceISSbiological_process
GO:0034384High-density lipoprotein particle clearanceIDAbiological_process
GO:0042060Wound healingTASbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042632Cholesterol homeostasisISSbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043534Blood vessel endothelial cell migrationIEAbiological_process
GO:0043654Recognition of apoptotic cellIDAbiological_process
GO:0043691Reverse cholesterol transportIEPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050764Regulation of phagocytosisICbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityIDAbiological_process
GO:0051856Adhesion to symbiontIMPbiological_process
GO:0070328Triglyceride homeostasisISSbiological_process
GO:0070506High-density lipoprotein particle receptor activityIDAmolecular_function
GO:0070508Cholesterol importISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02697376620.77380202500.38205045671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0221063630
GSE13712_SHEARUp0.2923259393
GSE13712_STATICUp0.4027430392
GSE19018Down-0.0278237849
GSE19899_A1Up0.1208045850
GSE19899_A2Up0.9459933710
PubMed_21979375_A1Up0.2841344340
PubMed_21979375_A2Up1.2150011679
GSE35957Down-0.0778944353
GSE36640Up0.2786095513
GSE54402Up0.1155363567
GSE9593Down-0.4068994001
GSE43922Up0.8039955264
GSE24585Down-1.1815300335
GSE37065Up0.8725871915
GSE28863_A1Up0.1761804838
GSE28863_A2Up0.2896125428
GSE28863_A3Down-0.0228508788
GSE28863_A4Up0.0388713801
GSE48662Up0.1034226814

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphatidyl serineDB00144 NUTR00048

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-185-5pMIMAT0000455MIRT035549Luciferase reporter assayFunctional MTI23459944
hsa-miR-96-5pMIMAT0000095MIRT035550Luciferase reporter assayFunctional MTI23459944
hsa-miR-223-3pMIMAT0000280MIRT035551Luciferase reporter assayFunctional MTI23459944
hsa-miR-877-3pMIMAT0004950MIRT037037CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040078CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043218CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049705CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

7541795The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids
7541795Using both direct binding and ligand competition assays in transfected cells, we have found that two class B scavenger receptors, SR-BI and CD36, can tightly bind PS and phosphatidylinositol (PI)-containing liposomes (Kd for PS liposome binding to SR-BI is approximately 15 micrograms phospholipid/ml or 0
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