HCSGD entry for SCARB1

1. General information

Official gene symbolSCARB1
Entrez ID949
Gene full namescavenger receptor class B, member 1
Other gene symbolsCD36L1 CLA-1 CLA1 HDLQTL6 SR-BI SRB1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001530Lipopolysaccharide bindingIDAmolecular_function
GO:0001786Phosphatidylserine bindingISSmolecular_function
GO:0001875Lipopolysaccharide receptor activityIDAmolecular_function
GO:0001935Endothelial cell proliferationIEAbiological_process
GO:0002221Pattern recognition receptor signaling pathwayIDAbiological_process
GO:0005215Transporter activityTASmolecular_function
GO:00055451-phosphatidylinositol bindingTASmolecular_function
GO:0005765Lysosomal membraneIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0005901CaveolaTAScellular_component
GO:0006702Androgen biosynthetic processIEAbiological_process
GO:0006707Cholesterol catabolic processIEAbiological_process
GO:0006898Receptor-mediated endocytosisIDAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007165Signal transductionIDAbiological_process
GO:0008035High-density lipoprotein particle bindingIEAmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0010595Positive regulation of endothelial cell migrationTASbiological_process
GO:0010867Positive regulation of triglyceride biosynthetic processISSbiological_process
GO:0010886Positive regulation of cholesterol storageIDAbiological_process
GO:0010899Regulation of phosphatidylcholine catabolic processISSbiological_process
GO:0015914Phospholipid transportISSbiological_process
GO:0015920Lipopolysaccharide transportIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016032Viral processIEAbiological_process
GO:0030169Low-density lipoprotein particle bindingIDAmolecular_function
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0031528Microvillus membraneIEAcellular_component
GO:0031663Lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0032497Detection of lipopolysaccharideIDAbiological_process
GO:0033344Cholesterol effluxISSbiological_process
GO:0034185Apolipoprotein bindingIPImolecular_function
GO:0034186Apolipoprotein A-I bindingIPImolecular_function
GO:0034375High-density lipoprotein particle remodelingISSbiological_process
GO:0034383Low-density lipoprotein particle clearanceISSbiological_process
GO:0034384High-density lipoprotein particle clearanceIDAbiological_process
GO:0042060Wound healingTASbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042632Cholesterol homeostasisISSbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0043534Blood vessel endothelial cell migrationIEAbiological_process
GO:0043654Recognition of apoptotic cellIDAbiological_process
GO:0043691Reverse cholesterol transportIEPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0050764Regulation of phagocytosisICbiological_process
GO:0051000Positive regulation of nitric-oxide synthase activityIDAbiological_process
GO:0051856Adhesion to symbiontIMPbiological_process
GO:0070328Triglyceride homeostasisISSbiological_process
GO:0070506High-density lipoprotein particle receptor activityIDAmolecular_function
GO:0070508Cholesterol importISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.02697376620.77380202500.38205045671.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0221063630
GSE13712_SHEARUp0.2923259393
GSE13712_STATICUp0.4027430392
GSE19018Down-0.0278237849
GSE19899_A1Up0.1208045850
GSE19899_A2Up0.9459933710
PubMed_21979375_A1Up0.2841344340
PubMed_21979375_A2Up1.2150011679
GSE35957Down-0.0778944353
GSE36640Up0.2786095513
GSE54402Up0.1155363567
GSE9593Down-0.4068994001
GSE43922Up0.8039955264
GSE24585Down-1.1815300335
GSE37065Up0.8725871915
GSE28863_A1Up0.1761804838
GSE28863_A2Up0.2896125428
GSE28863_A3Down-0.0228508788
GSE28863_A4Up0.0388713801
GSE48662Up0.1034226814

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Phosphatidyl serineDB00144 NUTR00048

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-185-5pMIMAT0000455MIRT035549Luciferase reporter assayFunctional MTI23459944
hsa-miR-96-5pMIMAT0000095MIRT035550Luciferase reporter assayFunctional MTI23459944
hsa-miR-223-3pMIMAT0000280MIRT035551Luciferase reporter assayFunctional MTI23459944
hsa-miR-877-3pMIMAT0004950MIRT037037CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040078CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043218CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049705CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

7541795The class B scavenger receptors SR-BI and CD36 are receptors for anionic phospholipids
7541795Using both direct binding and ligand competition assays in transfected cells, we have found that two class B scavenger receptors, SR-BI and CD36, can tightly bind PS and phosphatidylinositol (PI)-containing liposomes (Kd for PS liposome binding to SR-BI is approximately 15 micrograms phospholipid/ml or 0
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