HCSGD entry for MAPK8IP1

1. General information

Official gene symbolMAPK8IP1
Entrez ID9479
Gene full namemitogen-activated protein kinase 8 interacting protein 1
Other gene symbolsIB1 JIP-1 JIP1 PRKM8IP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004860Protein kinase inhibitor activityTASmolecular_function
GO:0005078MAP-kinase scaffold activityIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0007258JUN phosphorylationIEAbiological_process
GO:0008432JUN kinase bindingIEAmolecular_function
GO:0009967Positive regulation of signal transductionIPIbiological_process
GO:0016192Vesicle-mediated transportISSbiological_process
GO:0019894Kinesin bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031434Mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0042802Identical protein bindingIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043508Negative regulation of JUN kinase activityIEAbiological_process
GO:0044294Dendritic growth coneIEAcellular_component
GO:0044295Axonal growth coneIEAcellular_component
GO:0044297Cell bodyIEAcellular_component
GO:0044302Dentate gyrus mossy fiberIEAcellular_component
GO:0045202SynapseIEAcellular_component
GO:0046328Regulation of JNK cascadeISSbiological_process
GO:0046329Negative regulation of JNK cascadeIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41416382740.85329167960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0506358254
GSE13712_SHEARDown-0.1202752379
GSE13712_STATICDown-0.0426723003
GSE19018Up0.0786999693
GSE19899_A1Down-0.0038749915
GSE19899_A2Up0.2901037586
PubMed_21979375_A1Up0.1251239685
PubMed_21979375_A2Down-0.1961305146
GSE35957Up0.0503661846
GSE36640Up0.0927319271
GSE54402Up0.2153104124
GSE9593Up0.2069480509
GSE43922Up0.0557776191
GSE24585Down-0.0513172629
GSE37065Down-0.1592715202
GSE28863_A1Down-0.0143159100
GSE28863_A2Down-0.0836404191
GSE28863_A3Up0.1680429534
GSE28863_A4Up0.0395837486
GSE48662Up0.5386328598

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-OneDB01782 EXPT00232
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONEDB07218 -
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDEDB07272 -
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDEDB07276 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT004239MicroarrayFunctional MTI (Weak)16822819
hsa-miR-191-3pMIMAT0001618MIRT042394CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.