HCSGD entry for MAPK8IP1

1. General information

Official gene symbolMAPK8IP1
Entrez ID9479
Gene full namemitogen-activated protein kinase 8 interacting protein 1
Other gene symbolsIB1 JIP-1 JIP1 PRKM8IP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004860Protein kinase inhibitor activityTASmolecular_function
GO:0005078MAP-kinase scaffold activityIPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0007258JUN phosphorylationIEAbiological_process
GO:0008432JUN kinase bindingIEAmolecular_function
GO:0009967Positive regulation of signal transductionIPIbiological_process
GO:0016192Vesicle-mediated transportISSbiological_process
GO:0019894Kinesin bindingIPImolecular_function
GO:0019901Protein kinase bindingIPImolecular_function
GO:0031434Mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0031435Mitogen-activated protein kinase kinase kinase bindingIEAmolecular_function
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0042802Identical protein bindingIEAmolecular_function
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043508Negative regulation of JUN kinase activityIEAbiological_process
GO:0044294Dendritic growth coneIEAcellular_component
GO:0044295Axonal growth coneIEAcellular_component
GO:0044297Cell bodyIEAcellular_component
GO:0044302Dentate gyrus mossy fiberIEAcellular_component
GO:0045202SynapseIEAcellular_component
GO:0046328Regulation of JNK cascadeISSbiological_process
GO:0046329Negative regulation of JNK cascadeIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:2001243Negative regulation of intrinsic apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.41416382740.85329167960.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0506358254
GSE13712_SHEARDown-0.1202752379
GSE13712_STATICDown-0.0426723003
GSE19018Up0.0786999693
GSE19899_A1Down-0.0038749915
GSE19899_A2Up0.2901037586
PubMed_21979375_A1Up0.1251239685
PubMed_21979375_A2Down-0.1961305146
GSE35957Up0.0503661846
GSE36640Up0.0927319271
GSE54402Up0.2153104124
GSE9593Up0.2069480509
GSE43922Up0.0557776191
GSE24585Down-0.0513172629
GSE37065Down-0.1592715202
GSE28863_A1Down-0.0143159100
GSE28863_A2Down-0.0836404191
GSE28863_A3Up0.1680429534
GSE28863_A4Up0.0395837486
GSE48662Up0.5386328598

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-OneDB01782 EXPT00232
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONEDB07218 -
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDEDB07272 -
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDEDB07276 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT004239MicroarrayFunctional MTI (Weak)16822819
hsa-miR-191-3pMIMAT0001618MIRT042394CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.