HCSGD entry for PICK1

1. General information

Official gene symbolPICK1
Entrez ID9463
Gene full nameprotein interacting with PRKCA 1
Other gene symbolsPICK PRKCABP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002092Positive regulation of receptor internalizationISSbiological_process
GO:0005080Protein kinase C bindingISSmolecular_function
GO:0005102Receptor bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006468Protein phosphorylationISSbiological_process
GO:0006605Protein targetingIEAbiological_process
GO:0006890Retrograde vesicle-mediated transport, Golgi to ERNASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015844Monoamine transportIDAbiological_process
GO:0016887ATPase activityISSmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021782Glial cell developmentISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0034316Negative regulation of Arp2/3 complex-mediated actin nucleationISSbiological_process
GO:0036294Cellular response to decreased oxygen levelsISSbiological_process
GO:0042149Cellular response to glucose starvationISSbiological_process
GO:0042734Presynaptic membraneIDAcellular_component
GO:0043005Neuron projectionISScellular_component
GO:0043045DNA methylation involved in embryo developmentNASbiological_process
GO:0043046DNA methylation involved in gamete generationTASbiological_process
GO:0043113Receptor clusteringISSbiological_process
GO:0045161Neuronal ion channel clusteringTASbiological_process
GO:0045202SynapseISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmISScellular_component
GO:0051015Actin filament bindingISSmolecular_function
GO:0060292Long term synaptic depressionISSbiological_process
GO:0071933Arp2/3 complex bindingISSmolecular_function
GO:0097061Dendritic spine organizationISSbiological_process
GO:0097062Dendritic spine maintenanceISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84834551500.33160826340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0202782400
GSE13712_SHEARDown-0.1391937763
GSE13712_STATICUp0.2447647549
GSE19018Up0.2432353751
GSE19899_A1Down-0.2965032478
GSE19899_A2Up0.2309107354
PubMed_21979375_A1Down-0.2879782198
PubMed_21979375_A2Down-0.0291071401
GSE35957Up0.0131833050
GSE36640Down-0.2240400505
GSE54402Down-0.2337954445
GSE9593Up0.1588049509
GSE43922Down-0.2065432377
GSE24585Up0.0742071947
GSE37065Up0.0009160672
GSE28863_A1Down-0.1650369410
GSE28863_A2Down-0.1740586718
GSE28863_A3Down-0.1218500120
GSE28863_A4Up0.0146055828
GSE48662Up0.2285699957

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.