HCSGD entry for PICK1

1. General information

Official gene symbolPICK1
Entrez ID9463
Gene full nameprotein interacting with PRKCA 1
Other gene symbolsPICK PRKCABP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002092Positive regulation of receptor internalizationISSbiological_process
GO:0005080Protein kinase C bindingISSmolecular_function
GO:0005102Receptor bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006468Protein phosphorylationISSbiological_process
GO:0006605Protein targetingIEAbiological_process
GO:0006890Retrograde vesicle-mediated transport, Golgi to ERNASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015844Monoamine transportIDAbiological_process
GO:0016887ATPase activityISSmolecular_function
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021782Glial cell developmentISSbiological_process
GO:0030054Cell junctionIEAcellular_component
GO:0030666Endocytic vesicle membraneTAScellular_component
GO:0034316Negative regulation of Arp2/3 complex-mediated actin nucleationISSbiological_process
GO:0036294Cellular response to decreased oxygen levelsISSbiological_process
GO:0042149Cellular response to glucose starvationISSbiological_process
GO:0042734Presynaptic membraneIDAcellular_component
GO:0043005Neuron projectionISScellular_component
GO:0043045DNA methylation involved in embryo developmentNASbiological_process
GO:0043046DNA methylation involved in gamete generationTASbiological_process
GO:0043113Receptor clusteringISSbiological_process
GO:0045161Neuronal ion channel clusteringTASbiological_process
GO:0045202SynapseISScellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmISScellular_component
GO:0051015Actin filament bindingISSmolecular_function
GO:0060292Long term synaptic depressionISSbiological_process
GO:0071933Arp2/3 complex bindingISSmolecular_function
GO:0097061Dendritic spine organizationISSbiological_process
GO:0097062Dendritic spine maintenanceISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.84834551500.33160826340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0202782400
GSE13712_SHEARDown-0.1391937763
GSE13712_STATICUp0.2447647549
GSE19018Up0.2432353751
GSE19899_A1Down-0.2965032478
GSE19899_A2Up0.2309107354
PubMed_21979375_A1Down-0.2879782198
PubMed_21979375_A2Down-0.0291071401
GSE35957Up0.0131833050
GSE36640Down-0.2240400505
GSE54402Down-0.2337954445
GSE9593Up0.1588049509
GSE43922Down-0.2065432377
GSE24585Up0.0742071947
GSE37065Up0.0009160672
GSE28863_A1Down-0.1650369410
GSE28863_A2Down-0.1740586718
GSE28863_A3Down-0.1218500120
GSE28863_A4Up0.0146055828
GSE48662Up0.2285699957

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.