HCSGD entry for ARHGEF6

1. General information

Official gene symbolARHGEF6
Entrez ID9459
Gene full nameRac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Other gene symbolsCOOL2 Cool-2 MRX46 PIXA alpha-PIX alphaPIX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005089Rho guanyl-nucleotide exchange factor activityIEA NASmolecular_function
GO:0005096GTPase activator activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularICcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processNASbiological_process
GO:0007254JNK cascadeNASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0030027LamellipodiumISScellular_component
GO:0030032Lamellipodium assemblyISSbiological_process
GO:0032318Regulation of Ras GTPase activityNASbiological_process
GO:0032319Regulation of Rho GTPase activityNASbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043085Positive regulation of catalytic activityNASbiological_process
GO:0043087Regulation of GTPase activityNASbiological_process
GO:0043547Positive regulation of GTPase activityNASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050790Regulation of catalytic activityNASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96610669810.00146163140.99999024730.0742694981

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4909502874
GSE13712_SHEARDown-2.5216760523
GSE13712_STATICDown-2.4164448447
GSE19018Up0.5259230495
GSE19899_A1Down-0.7428996454
GSE19899_A2Down-1.3034801878
PubMed_21979375_A1Down-0.3857205581
PubMed_21979375_A2Down-0.9624488590
GSE35957Down-0.9293618620
GSE36640Up0.3982018112
GSE54402Down-1.0368369353
GSE9593Down-0.0931132343
GSE43922Down-0.3166168864
GSE24585Down-0.2271897979
GSE37065Up0.4734070476
GSE28863_A1Up0.0348878865
GSE28863_A2Down-0.2260589504
GSE28863_A3Down-0.4033952099
GSE28863_A4Down-0.0468885671
GSE48662Down-0.0903759910

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30c-5pMIMAT0000244MIRT007134qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-877-5pMIMAT0004949MIRT037230CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.