HCSGD entry for ARHGEF6

1. General information

Official gene symbolARHGEF6
Entrez ID9459
Gene full nameRac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Other gene symbolsCOOL2 Cool-2 MRX46 PIXA alpha-PIX alphaPIX
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005089Rho guanyl-nucleotide exchange factor activityIEA NASmolecular_function
GO:0005096GTPase activator activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularICcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006915Apoptotic processNASbiological_process
GO:0007254JNK cascadeNASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0030027LamellipodiumISScellular_component
GO:0030032Lamellipodium assemblyISSbiological_process
GO:0032318Regulation of Ras GTPase activityNASbiological_process
GO:0032319Regulation of Rho GTPase activityNASbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043085Positive regulation of catalytic activityNASbiological_process
GO:0043087Regulation of GTPase activityNASbiological_process
GO:0043547Positive regulation of GTPase activityNASbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050790Regulation of catalytic activityNASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96610669810.00146163140.99999024730.0742694981

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4909502874
GSE13712_SHEARDown-2.5216760523
GSE13712_STATICDown-2.4164448447
GSE19018Up0.5259230495
GSE19899_A1Down-0.7428996454
GSE19899_A2Down-1.3034801878
PubMed_21979375_A1Down-0.3857205581
PubMed_21979375_A2Down-0.9624488590
GSE35957Down-0.9293618620
GSE36640Up0.3982018112
GSE54402Down-1.0368369353
GSE9593Down-0.0931132343
GSE43922Down-0.3166168864
GSE24585Down-0.2271897979
GSE37065Up0.4734070476
GSE28863_A1Up0.0348878865
GSE28863_A2Down-0.2260589504
GSE28863_A3Down-0.4033952099
GSE28863_A4Down-0.0468885671
GSE48662Down-0.0903759910

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30c-5pMIMAT0000244MIRT007134qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-877-5pMIMAT0004949MIRT037230CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.