HCSGD entry for LRAT

1. General information

Official gene symbolLRAT
Entrez ID9227
Gene full namelecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Other gene symbolsLCA14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001972Retinoic acid bindingIEAmolecular_function
GO:0005771Multivesicular bodyIEA ISScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005791Rough endoplasmic reticulumIEA ISScellular_component
GO:0006776Vitamin A metabolic processIEAbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016746Transferase activity, transferring acyl groupsTASmolecular_function
GO:0019841Retinol bindingIEAmolecular_function
GO:0042572Retinol metabolic processIEAbiological_process
GO:0042573Retinoic acid metabolic processIEAbiological_process
GO:0047173Phosphatidylcholine-retinol O-acyltransferase activityIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16332451270.90562028800.80050595681.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1566170668
GSE13712_SHEARDown-0.1060696923
GSE13712_STATICDown-0.4383661341
GSE19018Up0.2778497334
GSE19899_A1Up0.1749585874
GSE19899_A2Down-0.0785458245
PubMed_21979375_A1Up0.0232119571
PubMed_21979375_A2Up0.0554245168
GSE35957Up0.0942245810
GSE36640Down-0.1059168804
GSE54402Up0.1053469691
GSE9593Up0.0445862311
GSE43922Up0.0144240991
GSE24585Up0.8805270070
GSE37065Up0.0199818376
GSE28863_A1Up0.0096301190
GSE28863_A2Up0.1505227208
GSE28863_A3Up0.3632421760
GSE28863_A4Up0.0776254548
GSE48662Up0.0436604868

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Vitamin ADB00162 NUTR00007 | APRD00486

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017703MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.