HCSGD entry for LRAT

1. General information

Official gene symbolLRAT
Entrez ID9227
Gene full namelecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Other gene symbolsLCA14
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001523Retinoid metabolic processTASbiological_process
GO:0001972Retinoic acid bindingIEAmolecular_function
GO:0005771Multivesicular bodyIEA ISScellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005791Rough endoplasmic reticulumIEA ISScellular_component
GO:0006776Vitamin A metabolic processIEAbiological_process
GO:0007601Visual perceptionIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0009790Embryo developmentIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016746Transferase activity, transferring acyl groupsTASmolecular_function
GO:0019841Retinol bindingIEAmolecular_function
GO:0042572Retinol metabolic processIEAbiological_process
GO:0042573Retinoic acid metabolic processIEAbiological_process
GO:0047173Phosphatidylcholine-retinol O-acyltransferase activityIEAmolecular_function
GO:0048471Perinuclear region of cytoplasmIEA ISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.16332451270.90562028800.80050595681.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1566170668
GSE13712_SHEARDown-0.1060696923
GSE13712_STATICDown-0.4383661341
GSE19018Up0.2778497334
GSE19899_A1Up0.1749585874
GSE19899_A2Down-0.0785458245
PubMed_21979375_A1Up0.0232119571
PubMed_21979375_A2Up0.0554245168
GSE35957Up0.0942245810
GSE36640Down-0.1059168804
GSE54402Up0.1053469691
GSE9593Up0.0445862311
GSE43922Up0.0144240991
GSE24585Up0.8805270070
GSE37065Up0.0199818376
GSE28863_A1Up0.0096301190
GSE28863_A2Up0.1505227208
GSE28863_A3Up0.3632421760
GSE28863_A4Up0.0776254548
GSE48662Up0.0436604868

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Vitamin ADB00162 NUTR00007 | APRD00486

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017703MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.