HCSGD entry for ACVR2A
1. General information
| Official gene symbol | ACVR2A |
|---|---|
| Entrez ID | 92 |
| Gene full name | activin A receptor, type IIA |
| Other gene symbols | ACTRII ACVR2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001702 | Gastrulation with mouth forming second | IEA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IMP | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | EXP | molecular_function |
| GO:0004675 | Transmembrane receptor protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0004702 | Receptor signaling protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0005024 | Transforming growth factor beta-activated receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007178 | Transmembrane receptor protein serine/threonine kinase signaling pathway | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007368 | Determination of left/right symmetry | IEA | biological_process |
| GO:0007498 | Mesoderm development | IEA | biological_process |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0010862 | Positive regulation of pathway-restricted SMAD protein phosphorylation | IMP | biological_process |
| GO:0015026 | Coreceptor activity | IDA | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0017002 | Activin-activated receptor activity | IDA | molecular_function |
| GO:0019838 | Growth factor binding | IEA | molecular_function |
| GO:0030165 | PDZ domain binding | IEA | molecular_function |
| GO:0030501 | Positive regulation of bone mineralization | IMP | biological_process |
| GO:0030509 | BMP signaling pathway | IDA IEA IMP TAS | biological_process |
| GO:0030510 | Regulation of BMP signaling pathway | IEA | biological_process |
| GO:0032924 | Activin receptor signaling pathway | IDA | biological_process |
| GO:0032927 | Positive regulation of activin receptor signaling pathway | IDA | biological_process |
| GO:0034673 | Inhibin-betaglycan-ActRII complex | IDA | cellular_component |
| GO:0034711 | Inhibin binding | IEA | molecular_function |
| GO:0042713 | Sperm ejaculation | IEA | biological_process |
| GO:0043084 | Penile erection | IEA | biological_process |
| GO:0043621 | Protein self-association | IEA | molecular_function |
| GO:0045648 | Positive regulation of erythrocyte differentiation | IDA | biological_process |
| GO:0045669 | Positive regulation of osteoblast differentiation | IMP | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048185 | Activin binding | IEA IPI | molecular_function |
| GO:0048706 | Embryonic skeletal system development | IEA | biological_process |
| GO:0050999 | Regulation of nitric-oxide synthase activity | IEA | biological_process |
| GO:0060011 | Sertoli cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0702226891 | 0.0226844231 | 0.5661045636 | 0.2898489320 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.9401418275 |
| GSE13712_SHEAR | Down | -0.5925550819 |
| GSE13712_STATIC | Down | -0.2319557774 |
| GSE19018 | Down | -0.8604207627 |
| GSE19899_A1 | Up | 0.1253471996 |
| GSE19899_A2 | Up | 0.1778792181 |
| PubMed_21979375_A1 | Down | -0.4018035064 |
| PubMed_21979375_A2 | Up | 0.4424192203 |
| GSE35957 | Up | 0.5411518233 |
| GSE36640 | Up | 0.2700916769 |
| GSE54402 | Down | -0.0572432594 |
| GSE9593 | Down | -1.0490288333 |
| GSE43922 | Up | 0.2862480645 |
| GSE24585 | Up | 0.2003893543 |
| GSE37065 | Down | -0.6452513821 |
| GSE28863_A1 | Up | 1.4807864897 |
| GSE28863_A2 | Up | 1.1744997179 |
| GSE28863_A3 | Down | -0.5870315321 |
| GSE28863_A4 | Down | -0.4966604373 |
| GSE48662 | Up | 0.7846287786 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT000536 | Luciferase reporter assay//Western blot | Functional MTI | 20216554 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT021134 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT025616 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026448 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
