HCSGD entry for ACVR2A

1. General information

Official gene symbolACVR2A
Entrez ID92
Gene full nameactivin A receptor, type IIA
Other gene symbolsACTRII ACVR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIMPbiological_process
GO:0004674Protein serine/threonine kinase activityEXPmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityTASmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007178Transmembrane receptor protein serine/threonine kinase signaling pathwayTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0007368Determination of left/right symmetryIEAbiological_process
GO:0007498Mesoderm developmentIEAbiological_process
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0009986Cell surfaceIEAcellular_component
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIMPbiological_process
GO:0015026Coreceptor activityIDAmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0017002Activin-activated receptor activityIDAmolecular_function
GO:0019838Growth factor bindingIEAmolecular_function
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0030501Positive regulation of bone mineralizationIMPbiological_process
GO:0030509BMP signaling pathwayIDA IEA IMP TASbiological_process
GO:0030510Regulation of BMP signaling pathwayIEAbiological_process
GO:0032924Activin receptor signaling pathwayIDAbiological_process
GO:0032927Positive regulation of activin receptor signaling pathwayIDAbiological_process
GO:0034673Inhibin-betaglycan-ActRII complexIDAcellular_component
GO:0034711Inhibin bindingIEAmolecular_function
GO:0042713Sperm ejaculationIEAbiological_process
GO:0043084Penile erectionIEAbiological_process
GO:0043621Protein self-associationIEAmolecular_function
GO:0045648Positive regulation of erythrocyte differentiationIDAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048185Activin bindingIEA IPImolecular_function
GO:0048706Embryonic skeletal system developmentIEAbiological_process
GO:0050999Regulation of nitric-oxide synthase activityIEAbiological_process
GO:0060011Sertoli cell proliferationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07022268910.02268442310.56610456360.2898489320

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.9401418275
GSE13712_SHEARDown-0.5925550819
GSE13712_STATICDown-0.2319557774
GSE19018Down-0.8604207627
GSE19899_A1Up0.1253471996
GSE19899_A2Up0.1778792181
PubMed_21979375_A1Down-0.4018035064
PubMed_21979375_A2Up0.4424192203
GSE35957Up0.5411518233
GSE36640Up0.2700916769
GSE54402Down-0.0572432594
GSE9593Down-1.0490288333
GSE43922Up0.2862480645
GSE24585Up0.2003893543
GSE37065Down-0.6452513821
GSE28863_A1Up1.4807864897
GSE28863_A2Up1.1744997179
GSE28863_A3Down-0.5870315321
GSE28863_A4Down-0.4966604373
GSE48662Up0.7846287786

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT000536Luciferase reporter assay//Western blotFunctional MTI20216554
hsa-miR-186-5pMIMAT0000456MIRT021134SequencingFunctional MTI (Weak)20371350
hsa-miR-10a-5pMIMAT0000253MIRT025616SequencingFunctional MTI (Weak)20371350
hsa-miR-192-5pMIMAT0000222MIRT026448MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.