HCSGD entry for CD2
1. General information
| Official gene symbol | CD2 |
|---|---|
| Entrez ID | 914 |
| Gene full name | CD2 molecule |
| Other gene symbols | LFA-2 SRBC T11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001766 | Membrane raft polarization | TAS | biological_process |
| GO:0004872 | Receptor activity | IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | NAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IDA | cellular_component |
| GO:0009898 | Cytoplasmic side of plasma membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016337 | Cell-cell adhesion | NAS | biological_process |
| GO:0030101 | Natural killer cell activation | NAS | biological_process |
| GO:0030887 | Positive regulation of myeloid dendritic cell activation | NAS | biological_process |
| GO:0042110 | T cell activation | TAS | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0045580 | Regulation of T cell differentiation | NAS | biological_process |
| GO:0046658 | Anchored component of plasma membrane | IEA | cellular_component |
| GO:0050900 | Leukocyte migration | TAS | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5638936249 | 0.8348799324 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2029818832 |
| GSE13712_SHEAR | Down | -0.0933947468 |
| GSE13712_STATIC | Up | 0.2051134857 |
| GSE19018 | Up | 0.0315028753 |
| GSE19899_A1 | Down | -0.0503415764 |
| GSE19899_A2 | Up | 0.1782978381 |
| PubMed_21979375_A1 | Down | -0.0703755616 |
| PubMed_21979375_A2 | Down | -0.2014887141 |
| GSE35957 | Up | 0.1790752661 |
| GSE36640 | Up | 0.0252243976 |
| GSE54402 | Up | 0.0855408867 |
| GSE9593 | Up | 0.3706370905 |
| GSE43922 | Up | 0.0306554603 |
| GSE24585 | Up | 0.0803486797 |
| GSE37065 | Up | 0.0053954087 |
| GSE28863_A1 | Down | -0.0016127620 |
| GSE28863_A2 | Up | 0.1026985757 |
| GSE28863_A3 | Up | 0.0740456213 |
| GSE28863_A4 | Up | 0.0444333723 |
| GSE48662 | Up | 0.0833937480 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alefacept | DB00092 | BTD00055 | BIOD00055 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21300823 | CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis |
| 21300823 | When isolated from patients with multiple sclerosis, both the nonmature and the effector subsets of memory CD127(lo) Tregs exhibited kinetically distinct defects in suppression that were evident with CD2 costimulation |
Entries Per Page
Displaying Page of
