HCSGD entry for CD2

1. General information

Official gene symbolCD2
Entrez ID914
Gene full nameCD2 molecule
Other gene symbolsLFA-2 SRBC T11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001766Membrane raft polarizationTASbiological_process
GO:0004872Receptor activityIEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneNAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0009898Cytoplasmic side of plasma membraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016337Cell-cell adhesionNASbiological_process
GO:0030101Natural killer cell activationNASbiological_process
GO:0030887Positive regulation of myeloid dendritic cell activationNASbiological_process
GO:0042110T cell activationTASbiological_process
GO:0042803Protein homodimerization activityIEAmolecular_function
GO:0045580Regulation of T cell differentiationNASbiological_process
GO:0046658Anchored component of plasma membraneIEAcellular_component
GO:0050900Leukocyte migrationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.56389362490.83487993240.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2029818832
GSE13712_SHEARDown-0.0933947468
GSE13712_STATICUp0.2051134857
GSE19018Up0.0315028753
GSE19899_A1Down-0.0503415764
GSE19899_A2Up0.1782978381
PubMed_21979375_A1Down-0.0703755616
PubMed_21979375_A2Down-0.2014887141
GSE35957Up0.1790752661
GSE36640Up0.0252243976
GSE54402Up0.0855408867
GSE9593Up0.3706370905
GSE43922Up0.0306554603
GSE24585Up0.0803486797
GSE37065Up0.0053954087
GSE28863_A1Down-0.0016127620
GSE28863_A2Up0.1026985757
GSE28863_A3Up0.0740456213
GSE28863_A4Up0.0444333723
GSE48662Up0.0833937480

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AlefaceptDB00092 BTD00055 | BIOD00055

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21300823CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis
21300823When isolated from patients with multiple sclerosis, both the nonmature and the effector subsets of memory CD127(lo) Tregs exhibited kinetically distinct defects in suppression that were evident with CD2 costimulation
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