HCSGD entry for P2RX6
1. General information
| Official gene symbol | P2RX6 |
|---|---|
| Entrez ID | 9127 |
| Gene full name | purinergic receptor P2X, ligand-gated ion channel, 6 |
| Other gene symbols | P2RXL1 P2X6 P2XM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001614 | Purinergic nucleotide receptor activity | IBA IEA NAS | molecular_function |
| GO:0004888 | Transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0004931 | Extracellular ATP-gated cation channel activity | IBA NAS | molecular_function |
| GO:0005216 | Ion channel activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA NAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0006812 | Cation transport | IBA | biological_process |
| GO:0006936 | Muscle contraction | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0014069 | Postsynaptic density | IEA | cellular_component |
| GO:0015267 | Channel activity | TAS | molecular_function |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030054 | Cell junction | IDA | cellular_component |
| GO:0034220 | Ion transmembrane transport | IBA NAS | biological_process |
| GO:0035587 | Purinergic receptor signaling pathway | IBA NAS | biological_process |
| GO:0035590 | Purinergic nucleotide receptor signaling pathway | IBA NAS | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0051260 | Protein homooligomerization | IPI | biological_process |
| GO:0051291 | Protein heterooligomerization | IEA | biological_process |
| GO:0055085 | Transmembrane transport | IBA NAS TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5565695148 | 0.6380575890 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0692990289 |
| GSE13712_SHEAR | Up | 0.1405386925 |
| GSE13712_STATIC | Up | 0.0237491296 |
| GSE19018 | Down | -0.0598986885 |
| GSE19899_A1 | Down | -0.0307459069 |
| GSE19899_A2 | Up | 0.1608820975 |
| PubMed_21979375_A1 | Down | -0.1509231165 |
| PubMed_21979375_A2 | Down | -0.0403787535 |
| GSE35957 | Up | 0.1486728740 |
| GSE36640 | Up | 0.0393390519 |
| GSE54402 | Down | -0.0234700222 |
| GSE9593 | Down | -0.0342323415 |
| GSE43922 | Up | 0.0257168614 |
| GSE24585 | Up | 0.1532097612 |
| GSE37065 | Down | -0.0981532340 |
| GSE28863_A1 | Down | -0.2916085505 |
| GSE28863_A2 | Down | -0.3179148362 |
| GSE28863_A3 | Up | 0.3975586575 |
| GSE28863_A4 | Up | 0.2908013376 |
| GSE48662 | Up | 0.1753648581 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-3p | MIMAT0000071 | MIRT050743 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
