HCSGD entry for P2RX6

1. General information

Official gene symbolP2RX6
Entrez ID9127
Gene full namepurinergic receptor P2X, ligand-gated ion channel, 6
Other gene symbolsP2RXL1 P2X6 P2XM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001614Purinergic nucleotide receptor activityIBA IEA NASmolecular_function
GO:0004888Transmembrane signaling receptor activityTASmolecular_function
GO:0004931Extracellular ATP-gated cation channel activityIBA NASmolecular_function
GO:0005216Ion channel activityIEAmolecular_function
GO:0005524ATP bindingIEA NASmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006810TransportTASbiological_process
GO:0006812Cation transportIBAbiological_process
GO:0006936Muscle contractionTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0015267Channel activityTASmolecular_function
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0030054Cell junctionIDAcellular_component
GO:0034220Ion transmembrane transportIBA NASbiological_process
GO:0035587Purinergic receptor signaling pathwayIBA NASbiological_process
GO:0035590Purinergic nucleotide receptor signaling pathwayIBA NASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0051260Protein homooligomerizationIPIbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0055085Transmembrane transportIBA NAS TASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55656951480.63805758900.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0692990289
GSE13712_SHEARUp0.1405386925
GSE13712_STATICUp0.0237491296
GSE19018Down-0.0598986885
GSE19899_A1Down-0.0307459069
GSE19899_A2Up0.1608820975
PubMed_21979375_A1Down-0.1509231165
PubMed_21979375_A2Down-0.0403787535
GSE35957Up0.1486728740
GSE36640Up0.0393390519
GSE54402Down-0.0234700222
GSE9593Down-0.0342323415
GSE43922Up0.0257168614
GSE24585Up0.1532097612
GSE37065Down-0.0981532340
GSE28863_A1Down-0.2916085505
GSE28863_A2Down-0.3179148362
GSE28863_A3Up0.3975586575
GSE28863_A4Up0.2908013376
GSE48662Up0.1753648581

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-17-3pMIMAT0000071MIRT050743CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.