HCSGD entry for RNF8

1. General information

Official gene symbolRNF8
Entrez ID9025
Gene full namering finger protein 8, E3 ubiquitin protein ligase
Other gene symbolshRNF8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000151Ubiquitin ligase complexIDAcellular_component
GO:0000781Chromosome, telomeric regionISScellular_component
GO:0003682Chromatin bindingIDAmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0006302Double-strand break repairIDAbiological_process
GO:0006303Double-strand break repair via nonhomologous end joiningISSbiological_process
GO:0006511Ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDA IEAbiological_process
GO:0007067MitosisIEAbiological_process
GO:0007286Spermatid developmentISSbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0010212Response to ionizing radiationIDAbiological_process
GO:0016567Protein ubiquitinationIEAbiological_process
GO:0016881Acid-amino acid ligase activityIEAmolecular_function
GO:0030496MidbodyIEAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0033522Histone H2A ubiquitinationIDAbiological_process
GO:0033523Histone H2B ubiquitinationISSbiological_process
GO:0035861Site of double-strand breakIDAcellular_component
GO:0036297Interstrand cross-link repairTASbiological_process
GO:0042393Histone bindingIDAmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043486Histone exchangeISSbiological_process
GO:0045190Isotype switchingISSbiological_process
GO:0045739Positive regulation of DNA repairIDAbiological_process
GO:0045900Negative regulation of translational elongationIMPbiological_process
GO:0051301Cell divisionIEAbiological_process
GO:0051865Protein autoubiquitinationIDAbiological_process
GO:0070534Protein K63-linked ubiquitinationIDAbiological_process
GO:0070535Histone H2A K63-linked ubiquitinationIDA IMPbiological_process
GO:0070936Protein K48-linked ubiquitinationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55524195130.62119063490.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1679998015
GSE13712_SHEARUp0.0303714522
GSE13712_STATICDown-0.0892894119
GSE19018Down-0.0183078195
GSE19899_A1Down-0.0745918745
GSE19899_A2Up0.0332458369
PubMed_21979375_A1Up0.0022710579
PubMed_21979375_A2Up0.1526216558
GSE35957Down-0.1336923268
GSE36640Down-0.0770182069
GSE54402Up0.0652059207
GSE9593Down-0.0119670446
GSE43922Up0.0313960337
GSE24585Down-0.7003645805
GSE37065Up0.1055039141
GSE28863_A1Up0.2467955079
GSE28863_A2Up0.6230445165
GSE28863_A3Up0.1045131758
GSE28863_A4Down-0.1454593315
GSE48662Down-0.0387653877

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25171524Double strand break (DSB) repair is suppressed during mitosis because RNF8 and downstream DNA damage response (DDR) factors, including 53BP1, do not localize to mitotic chromatin
18001825RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
18001825Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA-damage response
18001825We have shown that RNF8 facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged chromatin, on one hand through the phospho-dependent FHA domain-mediated binding of RNF8 to MDC1, on the other hand via its role in ubiquitylating H2AX and possibly other substrates at damage sites
18001825Together, our study implicates RNF8 as a novel DNA-damage-responsive protein that integrates protein phosphorylation and ubiquitylation signaling and plays a critical role in the cellular response to genotoxic stress
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