HCSGD entry for RNF8
1. General information
| Official gene symbol | RNF8 |
|---|---|
| Entrez ID | 9025 |
| Gene full name | ring finger protein 8, E3 ubiquitin protein ligase |
| Other gene symbols | hRNF8 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000151 | Ubiquitin ligase complex | IDA | cellular_component |
| GO:0000781 | Chromosome, telomeric region | ISS | cellular_component |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0004842 | Ubiquitin-protein ligase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006302 | Double-strand break repair | IDA | biological_process |
| GO:0006303 | Double-strand break repair via nonhomologous end joining | ISS | biological_process |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA IEA | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0007286 | Spermatid development | ISS | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0010212 | Response to ionizing radiation | IDA | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0016881 | Acid-amino acid ligase activity | IEA | molecular_function |
| GO:0030496 | Midbody | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IPI | molecular_function |
| GO:0033522 | Histone H2A ubiquitination | IDA | biological_process |
| GO:0033523 | Histone H2B ubiquitination | ISS | biological_process |
| GO:0035861 | Site of double-strand break | IDA | cellular_component |
| GO:0036297 | Interstrand cross-link repair | TAS | biological_process |
| GO:0042393 | Histone binding | IDA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA | molecular_function |
| GO:0043486 | Histone exchange | ISS | biological_process |
| GO:0045190 | Isotype switching | ISS | biological_process |
| GO:0045739 | Positive regulation of DNA repair | IDA | biological_process |
| GO:0045900 | Negative regulation of translational elongation | IMP | biological_process |
| GO:0051301 | Cell division | IEA | biological_process |
| GO:0051865 | Protein autoubiquitination | IDA | biological_process |
| GO:0070534 | Protein K63-linked ubiquitination | IDA | biological_process |
| GO:0070535 | Histone H2A K63-linked ubiquitination | IDA IMP | biological_process |
| GO:0070936 | Protein K48-linked ubiquitination | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5552419513 | 0.6211906349 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1679998015 |
| GSE13712_SHEAR | Up | 0.0303714522 |
| GSE13712_STATIC | Down | -0.0892894119 |
| GSE19018 | Down | -0.0183078195 |
| GSE19899_A1 | Down | -0.0745918745 |
| GSE19899_A2 | Up | 0.0332458369 |
| PubMed_21979375_A1 | Up | 0.0022710579 |
| PubMed_21979375_A2 | Up | 0.1526216558 |
| GSE35957 | Down | -0.1336923268 |
| GSE36640 | Down | -0.0770182069 |
| GSE54402 | Up | 0.0652059207 |
| GSE9593 | Down | -0.0119670446 |
| GSE43922 | Up | 0.0313960337 |
| GSE24585 | Down | -0.7003645805 |
| GSE37065 | Up | 0.1055039141 |
| GSE28863_A1 | Up | 0.2467955079 |
| GSE28863_A2 | Up | 0.6230445165 |
| GSE28863_A3 | Up | 0.1045131758 |
| GSE28863_A4 | Down | -0.1454593315 |
| GSE48662 | Down | -0.0387653877 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25171524 | Double strand break (DSB) repair is suppressed during mitosis because RNF8 and downstream DNA damage response (DDR) factors, including 53BP1, do not localize to mitotic chromatin |
| 18001825 | RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly |
| 18001825 | Here we show that RNF8, a FHA/RING domain-containing protein, plays a critical role in the early DNA-damage response |
| 18001825 | We have shown that RNF8 facilitates the accumulation of checkpoint mediator proteins BRCA1 and 53BP1 to the damaged chromatin, on one hand through the phospho-dependent FHA domain-mediated binding of RNF8 to MDC1, on the other hand via its role in ubiquitylating H2AX and possibly other substrates at damage sites |
| 18001825 | Together, our study implicates RNF8 as a novel DNA-damage-responsive protein that integrates protein phosphorylation and ubiquitylation signaling and plays a critical role in the cellular response to genotoxic stress |
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