HCSGD entry for ACVR1

1. General information

Official gene symbolACVR1
Entrez ID90
Gene full nameactivin A receptor, type I
Other gene symbolsACTRI ACVR1A ACVRLK2 ALK2 FOP SKR1 TSRI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001655Urogenital system developmentIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0002526Acute inflammatory responseIEAbiological_process
GO:0003143Embryonic heart tube morphogenesisIMPbiological_process
GO:0003183Mitral valve morphogenesisIMPbiological_process
GO:0003289Atrial septum primum morphogenesisIMPbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityRCAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005025Transforming growth factor beta receptor activity, type IIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDA IEAbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0007368Determination of left/right symmetryIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0009968Negative regulation of signal transductionIMPbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0016361Activin receptor activity, type IIDA IEAmolecular_function
GO:0017046Peptide hormone bindingNASmolecular_function
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0030278Regulation of ossificationIMPbiological_process
GO:0030501Positive regulation of bone mineralizationIMPbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0032924Activin receptor signaling pathwayIDAbiological_process
GO:0032926Negative regulation of activin receptor signaling pathwayIMPbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0045177Apical part of cellIEAcellular_component
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046332SMAD bindingIDA IEAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048179Activin receptor complexIDA IEAcellular_component
GO:0048185Activin bindingIDA IEAmolecular_function
GO:0048641Regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0050431Transforming growth factor beta bindingIDA IEAmolecular_function
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0060037Pharyngeal system developmentIEAbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060923Cardiac muscle cell fate commitmentIMPbiological_process
GO:0061445Endocardial cushion cell fate commitmentIMPbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
GO:2000017Positive regulation of determination of dorsal identityIDAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15163568250.37110221120.77732988711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0944300036
GSE13712_SHEARUp0.2938449165
GSE13712_STATICUp0.1545829233
GSE19018Down-0.5840609907
GSE19899_A1Up0.2385090218
GSE19899_A2Down-0.2695482482
PubMed_21979375_A1Up0.0190140504
PubMed_21979375_A2Up0.0512045772
GSE35957Down-0.0820568141
GSE36640Up0.8045942529
GSE54402Up0.0694520944
GSE9593Up0.5963962533
GSE43922Down-0.0450999267
GSE24585Up0.1322548334
GSE37065Up0.2887876948
GSE28863_A1Up0.4129911526
GSE28863_A2Up0.7316457944
GSE28863_A3Down-0.2043113839
GSE28863_A4Down-0.3208485430
GSE48662Down-0.6473293355

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidineDB08597 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT000216Microarray//qRT-PCRFunctional MTI (Weak)16822819
hsa-miR-148a-3pMIMAT0000243MIRT006946Luciferase reporter assayFunctional MTI22408438
hsa-miR-130a-3pMIMAT0000425MIRT007141qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-335-5pMIMAT0000765MIRT018362MicroarrayFunctional MTI (Weak)18185580
hsa-miR-130b-3pMIMAT0000691MIRT020339SequencingFunctional MTI (Weak)20371350
hsa-miR-186-5pMIMAT0000456MIRT021192SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031253SequencingFunctional MTI (Weak)20371350
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.