HCSGD entry for ACVR1

1. General information

Official gene symbolACVR1
Entrez ID90
Gene full nameactivin A receptor, type I
Other gene symbolsACTRI ACVR1A ACVRLK2 ALK2 FOP SKR1 TSRI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001655Urogenital system developmentIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001702Gastrulation with mouth forming secondIEAbiological_process
GO:0001707Mesoderm formationIEAbiological_process
GO:0001755Neural crest cell migrationIEAbiological_process
GO:0002526Acute inflammatory responseIEAbiological_process
GO:0003143Embryonic heart tube morphogenesisIMPbiological_process
GO:0003183Mitral valve morphogenesisIMPbiological_process
GO:0003289Atrial septum primum morphogenesisIMPbiological_process
GO:0004672Protein kinase activityIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0004675Transmembrane receptor protein serine/threonine kinase activityRCAmolecular_function
GO:0004702Receptor signaling protein serine/threonine kinase activityIEAmolecular_function
GO:0005025Transforming growth factor beta receptor activity, type IIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIDA IEAbiological_process
GO:0007281Germ cell developmentIEAbiological_process
GO:0007368Determination of left/right symmetryIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0009968Negative regulation of signal transductionIMPbiological_process
GO:0010862Positive regulation of pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0016361Activin receptor activity, type IIDA IEAmolecular_function
GO:0017046Peptide hormone bindingNASmolecular_function
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0030278Regulation of ossificationIMPbiological_process
GO:0030501Positive regulation of bone mineralizationIMPbiological_process
GO:0030509BMP signaling pathwayIDAbiological_process
GO:0032924Activin receptor signaling pathwayIDAbiological_process
GO:0032926Negative regulation of activin receptor signaling pathwayIMPbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0045177Apical part of cellIEAcellular_component
GO:0045669Positive regulation of osteoblast differentiationIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046332SMAD bindingIDA IEAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048179Activin receptor complexIDA IEAcellular_component
GO:0048185Activin bindingIDA IEAmolecular_function
GO:0048641Regulation of skeletal muscle tissue developmentIEAbiological_process
GO:0050431Transforming growth factor beta bindingIDA IEAmolecular_function
GO:0051145Smooth muscle cell differentiationIEAbiological_process
GO:0060037Pharyngeal system developmentIEAbiological_process
GO:0060389Pathway-restricted SMAD protein phosphorylationIDAbiological_process
GO:0060923Cardiac muscle cell fate commitmentIMPbiological_process
GO:0061445Endocardial cushion cell fate commitmentIMPbiological_process
GO:0071385Cellular response to glucocorticoid stimulusIEAbiological_process
GO:2000017Positive regulation of determination of dorsal identityIDAbiological_process
GO:2001237Negative regulation of extrinsic apoptotic signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15163568250.37110221120.77732988711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0944300036
GSE13712_SHEARUp0.2938449165
GSE13712_STATICUp0.1545829233
GSE19018Down-0.5840609907
GSE19899_A1Up0.2385090218
GSE19899_A2Down-0.2695482482
PubMed_21979375_A1Up0.0190140504
PubMed_21979375_A2Up0.0512045772
GSE35957Down-0.0820568141
GSE36640Up0.8045942529
GSE54402Up0.0694520944
GSE9593Up0.5963962533
GSE43922Down-0.0450999267
GSE24585Up0.1322548334
GSE37065Up0.2887876948
GSE28863_A1Up0.4129911526
GSE28863_A2Up0.7316457944
GSE28863_A3Down-0.2043113839
GSE28863_A4Down-0.3208485430
GSE48662Down-0.6473293355

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidineDB08597 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-197-3pMIMAT0000227MIRT000216Microarray//qRT-PCRFunctional MTI (Weak)16822819
hsa-miR-148a-3pMIMAT0000243MIRT006946Luciferase reporter assayFunctional MTI22408438
hsa-miR-130a-3pMIMAT0000425MIRT007141qRT-PCRFunctional MTI (Weak)23418453
hsa-miR-335-5pMIMAT0000765MIRT018362MicroarrayFunctional MTI (Weak)18185580
hsa-miR-130b-3pMIMAT0000691MIRT020339SequencingFunctional MTI (Weak)20371350
hsa-miR-186-5pMIMAT0000456MIRT021192SequencingFunctional MTI (Weak)20371350
hsa-miR-19b-3pMIMAT0000074MIRT031253SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.