HCSGD entry for WNT3A
1. General information
| Official gene symbol | WNT3A |
|---|---|
| Entrez ID | 89780 |
| Gene full name | wingless-type MMTV integration site family, member 3A |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001649 | Osteoblast differentiation | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0001947 | Heart looping | IEA | biological_process |
| GO:0002092 | Positive regulation of receptor internalization | IDA | biological_process |
| GO:0003136 | Negative regulation of heart induction by canonical Wnt signaling pathway | IDA | biological_process |
| GO:0003713 | Transcription coactivator activity | ISS | molecular_function |
| GO:0005109 | Frizzled binding | IBA | molecular_function |
| GO:0005110 | Frizzled-2 binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005615 | Extracellular space | IBA ISS | cellular_component |
| GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0007411 | Axon guidance | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | ISS | biological_process |
| GO:0009986 | Cell surface | ISS | cellular_component |
| GO:0010387 | COP9 signalosome assembly | ISS | biological_process |
| GO:0010469 | Regulation of receptor activity | IDA | biological_process |
| GO:0010977 | Negative regulation of neuron projection development | ISS | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0021527 | Spinal cord association neuron differentiation | IEA | biological_process |
| GO:0021766 | Hippocampus development | IEA | biological_process |
| GO:0021846 | Cell proliferation in forebrain | ISS | biological_process |
| GO:0021874 | Wnt signaling pathway involved in forebrain neuroblast division | IEA | biological_process |
| GO:0021904 | Dorsal/ventral neural tube patterning | IEA | biological_process |
| GO:0030097 | Hemopoiesis | IEA | biological_process |
| GO:0030182 | Neuron differentiation | IBA ISS | biological_process |
| GO:0030198 | Extracellular matrix organization | IEA | biological_process |
| GO:0030879 | Mammary gland development | IEA | biological_process |
| GO:0030890 | Positive regulation of B cell proliferation | IEA | biological_process |
| GO:0032092 | Positive regulation of protein binding | IDA | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0034613 | Cellular protein localization | IEA | biological_process |
| GO:0035413 | Positive regulation of catenin import into nucleus | IDA | biological_process |
| GO:0035914 | Skeletal muscle cell differentiation | IEA | biological_process |
| GO:0036342 | Post-anal tail morphogenesis | IEA | biological_process |
| GO:0042472 | Inner ear morphogenesis | IEA | biological_process |
| GO:0043280 | Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | IEA | biological_process |
| GO:0045599 | Negative regulation of fat cell differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0048018 | Receptor agonist activity | IDA | molecular_function |
| GO:0048337 | Positive regulation of mesodermal cell fate specification | IDA | biological_process |
| GO:0048343 | Paraxial mesodermal cell fate commitment | IEA | biological_process |
| GO:0048697 | Positive regulation of collateral sprouting in absence of injury | IEA | biological_process |
| GO:0048843 | Negative regulation of axon extension involved in axon guidance | IEA | biological_process |
| GO:0050768 | Negative regulation of neurogenesis | ISS | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IEA | biological_process |
| GO:0060021 | Palate development | IMP | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IDA | biological_process |
| GO:0061098 | Positive regulation of protein tyrosine kinase activity | IEA | biological_process |
| GO:0061184 | Positive regulation of dermatome development | IDA | biological_process |
| GO:0061317 | Canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment | IDA | biological_process |
| GO:0070507 | Regulation of microtubule cytoskeleton organization | IEA | biological_process |
| GO:0070527 | Platelet aggregation | IEA | biological_process |
| GO:0071300 | Cellular response to retinoic acid | ISS | biological_process |
| GO:0090245 | Axis elongation involved in somitogenesis | IEA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IDA | biological_process |
| GO:2000049 | Positive regulation of cell-cell adhesion mediated by cadherin | IEA | biological_process |
| GO:2000081 | Positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation | IEA | biological_process |
| GO:2000273 | Positive regulation of receptor activity | IDA | biological_process |
| GO:2000727 | Positive regulation of cardiac muscle cell differentiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3978285817 | 0.9646126173 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | - | - |
| GSE13712_SHEAR | - | - |
| GSE13712_STATIC | - | - |
| GSE19018 | - | - |
| GSE19899_A1 | - | - |
| GSE19899_A2 | - | - |
| PubMed_21979375_A1 | - | - |
| PubMed_21979375_A2 | - | - |
| GSE35957 | - | - |
| GSE36640 | - | - |
| GSE54402 | - | - |
| GSE9593 | - | - |
| GSE43922 | Up | 0.0909739291 |
| GSE24585 | Up | 0.0734816953 |
| GSE37065 | Down | -0.0360987982 |
| GSE28863_A1 | Down | -0.0399872326 |
| GSE28863_A2 | Up | 0.0790227721 |
| GSE28863_A3 | Up | 0.3087728716 |
| GSE28863_A4 | Up | 0.1261614538 |
| GSE48662 | Up | 0.0291200403 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-15a-5p | MIMAT0000068 | MIRT000282 | Luciferase reporter assay | Functional MTI | 18931683 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT003430 | Luciferase reporter assay | Functional MTI | 18931683 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT003430 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021725 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021973 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025061 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027132 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25437011 | A decline in Wnt3a signaling is necessary for mesenchymal stem cells to proceed to replicative senescence |
| 25437011 | Interestingly, the magnitude of the response to enhanced Wnt3a/beta-catenin signaling appears to depend on the senescent state during extended culture, particularly after multiple passages |
| 25437011 | These results suggest that Wnt3a signaling might be a predominant factor that could be used to overcome senescence in long-term cultured MSCs by directly intervening in the proliferative capacity and MSC senescence |
| 25437011 | The functional role of Wnt3a/beta-catenin signaling in hedging cellular senescence may allow the development of new approaches for stem cell-based therapies |
| 24853424 | Consistent with this observation, WIF1 caused a reduction in the expression of pluripotency and stemness markers (OCT4 and c-MYC), as well as adult stem cell self-renewal and multi-lineage differentiation markers, such as WNT3A, TCF4, c-KIT and MYB |
| 24659628 | A potential stimulus of miR-29 expression is Wnt-3a since we found that exogenous Wnt-3a stimulated miR-29 expression 2 |
| 24659628 | Thus, aging-induced muscle senescence results from activation of miR-29 by Wnt-3a leading to suppressed expression of several signaling proteins (p85alpha, IGF-1 and B-myb) that act coordinately to impair the proliferation of MPCs contributing to muscle atrophy |
| 22724383 | P53, p21, Wnt3a, Wnt5a, sonic hedgehog (Shh) mRNA was detected by Real time polymerase chain reaction (PCR) and Wnt5a protein was determined by Western blot |
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