HCSGD entry for WNT3A

1. General information

Official gene symbolWNT3A
Entrez ID89780
Gene full namewingless-type MMTV integration site family, member 3A
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIDAbiological_process
GO:0001947Heart loopingIEAbiological_process
GO:0002092Positive regulation of receptor internalizationIDAbiological_process
GO:0003136Negative regulation of heart induction by canonical Wnt signaling pathwayIDAbiological_process
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0005109Frizzled bindingIBAmolecular_function
GO:0005110Frizzled-2 bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005615Extracellular spaceIBA ISScellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005796Golgi lumenTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007411Axon guidanceIEAbiological_process
GO:0008284Positive regulation of cell proliferationISSbiological_process
GO:0009986Cell surfaceISScellular_component
GO:0010387COP9 signalosome assemblyISSbiological_process
GO:0010469Regulation of receptor activityIDAbiological_process
GO:0010977Negative regulation of neuron projection developmentISSbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021527Spinal cord association neuron differentiationIEAbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021846Cell proliferation in forebrainISSbiological_process
GO:0021874Wnt signaling pathway involved in forebrain neuroblast divisionIEAbiological_process
GO:0021904Dorsal/ventral neural tube patterningIEAbiological_process
GO:0030097HemopoiesisIEAbiological_process
GO:0030182Neuron differentiationIBA ISSbiological_process
GO:0030198Extracellular matrix organizationIEAbiological_process
GO:0030879Mammary gland developmentIEAbiological_process
GO:0030890Positive regulation of B cell proliferationIEAbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0033138Positive regulation of peptidyl-serine phosphorylationIDAbiological_process
GO:0034613Cellular protein localizationIEAbiological_process
GO:0035413Positive regulation of catenin import into nucleusIDAbiological_process
GO:0035914Skeletal muscle cell differentiationIEAbiological_process
GO:0036342Post-anal tail morphogenesisIEAbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0045599Negative regulation of fat cell differentiationIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048018Receptor agonist activityIDAmolecular_function
GO:0048337Positive regulation of mesodermal cell fate specificationIDAbiological_process
GO:0048343Paraxial mesodermal cell fate commitmentIEAbiological_process
GO:0048697Positive regulation of collateral sprouting in absence of injuryIEAbiological_process
GO:0048843Negative regulation of axon extension involved in axon guidanceIEAbiological_process
GO:0050768Negative regulation of neurogenesisISSbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIEAbiological_process
GO:0060021Palate developmentIMPbiological_process
GO:0060070Canonical Wnt signaling pathwayIDAbiological_process
GO:0061098Positive regulation of protein tyrosine kinase activityIEAbiological_process
GO:0061184Positive regulation of dermatome developmentIDAbiological_process
GO:0061317Canonical Wnt signaling pathway involved in cardiac muscle cell fate commitmentIDAbiological_process
GO:0070507Regulation of microtubule cytoskeleton organizationIEAbiological_process
GO:0070527Platelet aggregationIEAbiological_process
GO:0071300Cellular response to retinoic acidISSbiological_process
GO:0090245Axis elongation involved in somitogenesisIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIDAbiological_process
GO:2000049Positive regulation of cell-cell adhesion mediated by cadherinIEAbiological_process
GO:2000081Positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferationIEAbiological_process
GO:2000273Positive regulation of receptor activityIDAbiological_process
GO:2000727Positive regulation of cardiac muscle cell differentiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39782858170.96461261730.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954--
GSE13712_SHEAR--
GSE13712_STATIC--
GSE19018--
GSE19899_A1--
GSE19899_A2--
PubMed_21979375_A1--
PubMed_21979375_A2--
GSE35957--
GSE36640--
GSE54402--
GSE9593--
GSE43922Up0.0909739291
GSE24585Up0.0734816953
GSE37065Down-0.0360987982
GSE28863_A1Down-0.0399872326
GSE28863_A2Up0.0790227721
GSE28863_A3Up0.3087728716
GSE28863_A4Up0.1261614538
GSE48662Up0.0291200403

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-15a-5pMIMAT0000068MIRT000282Luciferase reporter assayFunctional MTI18931683
hsa-miR-16-5pMIMAT0000069MIRT003430Luciferase reporter assayFunctional MTI18931683
hsa-miR-16-5pMIMAT0000069MIRT003430SequencingFunctional MTI (Weak)20371350
hsa-miR-132-3pMIMAT0000426MIRT021725MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT021973MicroarrayFunctional MTI (Weak)17612493
hsa-miR-181a-5pMIMAT0000256MIRT025061MicroarrayFunctional MTI (Weak)17612493
hsa-miR-103a-3pMIMAT0000101MIRT027132SequencingFunctional MTI (Weak)20371350
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25437011A decline in Wnt3a signaling is necessary for mesenchymal stem cells to proceed to replicative senescence
25437011Interestingly, the magnitude of the response to enhanced Wnt3a/beta-catenin signaling appears to depend on the senescent state during extended culture, particularly after multiple passages
25437011These results suggest that Wnt3a signaling might be a predominant factor that could be used to overcome senescence in long-term cultured MSCs by directly intervening in the proliferative capacity and MSC senescence
25437011The functional role of Wnt3a/beta-catenin signaling in hedging cellular senescence may allow the development of new approaches for stem cell-based therapies
24853424Consistent with this observation, WIF1 caused a reduction in the expression of pluripotency and stemness markers (OCT4 and c-MYC), as well as adult stem cell self-renewal and multi-lineage differentiation markers, such as WNT3A, TCF4, c-KIT and MYB
24659628A potential stimulus of miR-29 expression is Wnt-3a since we found that exogenous Wnt-3a stimulated miR-29 expression 2
24659628Thus, aging-induced muscle senescence results from activation of miR-29 by Wnt-3a leading to suppressed expression of several signaling proteins (p85alpha, IGF-1 and B-myb) that act coordinately to impair the proliferation of MPCs contributing to muscle atrophy
22724383P53, p21, Wnt3a, Wnt5a, sonic hedgehog (Shh) mRNA was detected by Real time polymerase chain reaction (PCR) and Wnt5a protein was determined by Western blot
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