HCSGD entry for EIF2B3

1. General information

Official gene symbolEIF2B3
Entrez ID8891
Gene full nameeukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
Other gene symbolsEIF-2B EIF2Bgamma
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003743Translation initiation factor activityIDAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005851Eukaryotic translation initiation factor 2B complexIDAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationIDA TASbiological_process
GO:0008135Translation factor activity, nucleic acid bindingIDAmolecular_function
GO:0009058Biosynthetic processIEAbiological_process
GO:0009408Response to heatISS TASbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014003Oligodendrocyte developmentIMPbiological_process
GO:0016779Nucleotidyltransferase activityIEAmolecular_function
GO:0032057Negative regulation of translational initiation in response to stressISSbiological_process
GO:0043087Regulation of GTPase activityIDA IMPbiological_process
GO:0043434Response to peptide hormoneISSbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051716Cellular response to stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15440596100.42976944270.78201256491.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4924780288
GSE13712_SHEARUp0.0979168195
GSE13712_STATICUp0.1482929858
GSE19018Down-0.2914514660
GSE19899_A1Up0.5716166684
GSE19899_A2Up0.0881775936
PubMed_21979375_A1Up0.7532872827
PubMed_21979375_A2Down-0.2323917031
GSE35957Down-0.2934651276
GSE36640Up0.4652432756
GSE54402Up0.2080452829
GSE9593Down-0.1561560329
GSE43922Up0.0595649337
GSE24585Down-0.4701170272
GSE37065Down-0.0931423097
GSE28863_A1Up0.1177374760
GSE28863_A2Up0.0088450260
GSE28863_A3Down-0.3130366067
GSE28863_A4Down-0.0692736677
GSE48662Down-0.0066289138

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032349ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT039698CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044579CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.