HCSGD entry for EIF2B3

1. General information

Official gene symbolEIF2B3
Entrez ID8891
Gene full nameeukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
Other gene symbolsEIF-2B EIF2Bgamma
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003743Translation initiation factor activityIDAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005851Eukaryotic translation initiation factor 2B complexIDAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationIDA TASbiological_process
GO:0008135Translation factor activity, nucleic acid bindingIDAmolecular_function
GO:0009058Biosynthetic processIEAbiological_process
GO:0009408Response to heatISS TASbiological_process
GO:0009749Response to glucoseISSbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0014003Oligodendrocyte developmentIMPbiological_process
GO:0016779Nucleotidyltransferase activityIEAmolecular_function
GO:0032057Negative regulation of translational initiation in response to stressISSbiological_process
GO:0043087Regulation of GTPase activityIDA IMPbiological_process
GO:0043434Response to peptide hormoneISSbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051716Cellular response to stimulusIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.15440596100.42976944270.78201256491.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4924780288
GSE13712_SHEARUp0.0979168195
GSE13712_STATICUp0.1482929858
GSE19018Down-0.2914514660
GSE19899_A1Up0.5716166684
GSE19899_A2Up0.0881775936
PubMed_21979375_A1Up0.7532872827
PubMed_21979375_A2Down-0.2323917031
GSE35957Down-0.2934651276
GSE36640Up0.4652432756
GSE54402Up0.2080452829
GSE9593Down-0.1561560329
GSE43922Up0.0595649337
GSE24585Down-0.4701170272
GSE37065Down-0.0931423097
GSE28863_A1Up0.1177374760
GSE28863_A2Up0.0088450260
GSE28863_A3Down-0.3130366067
GSE28863_A4Down-0.0692736677
GSE48662Down-0.0066289138

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032349ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT039698CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044579CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.