HCSGD entry for DPM1

1. General information

Official gene symbolDPM1
Entrez ID8813
Gene full namedolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Other gene symbolsCDGIE MPDS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004169Dolichyl-phosphate-mannose-protein mannosyltransferase activityIDAmolecular_function
GO:0004582Dolichyl-phosphate beta-D-mannosyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005537Mannose bindingIEAmolecular_function
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIDA TAScellular_component
GO:0006488Dolichol-linked oligosaccharide biosynthetic processTASbiological_process
GO:0006501C-terminal protein lipidationTASbiological_process
GO:0006506GPI anchor biosynthetic processIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016757Transferase activity, transferring glycosyl groupsIEAmolecular_function
GO:0018279Protein N-linked glycosylation via asparagineTASbiological_process
GO:0019348Dolichol metabolic processIDAbiological_process
GO:0019673GDP-mannose metabolic processIEAbiological_process
GO:0033185Dolichol-phosphate-mannose synthase complexIDAcellular_component
GO:0035268Protein mannosylationIDAbiological_process
GO:0035269Protein O-linked mannosylationIDAbiological_process
GO:0043178Alcohol bindingIEAmolecular_function
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19881477150.84472508260.86147360541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0161859891
GSE13712_SHEARUp0.0614232637
GSE13712_STATICUp0.1468841010
GSE19018Down-0.0967346097
GSE19899_A1Up0.1846753881
GSE19899_A2Up0.1617629566
PubMed_21979375_A1Up0.5190058733
PubMed_21979375_A2Up0.4567548186
GSE35957Up0.0733946634
GSE36640Up0.1665918248
GSE54402Up0.2042709851
GSE9593Down-0.0194883653
GSE43922Down-0.0054371732
GSE24585Down-0.0268831835
GSE37065Up0.1119594885
GSE28863_A1Up0.2143186859
GSE28863_A2Up0.0492962458
GSE28863_A3Down-0.3860933136
GSE28863_A4Up0.3866624902
GSE48662Down-0.5876198084

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029861MicroarrayFunctional MTI (Weak)19088304
hsa-miR-18b-5pMIMAT0001412MIRT042406CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

10751218Human diploid fibroblasts (HDFs) underwent either 30 mean population doublings [mean population doublings (MPDs) thymidine labeling index (TI) >92% ("young") or between 53 and 58 MPDs (TI < 28%; "senescent")]
9535781We therefore measured cytosolic Ca2+ levels in 'young' (30 mean population doublings, MPDs) and 'senescent' (53 to 58 MPDs) human diploid fibroblasts (HDFs)
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