HCSGD entry for DPM1

1. General information

Official gene symbolDPM1
Entrez ID8813
Gene full namedolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Other gene symbolsCDGIE MPDS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004169Dolichyl-phosphate-mannose-protein mannosyltransferase activityIDAmolecular_function
GO:0004582Dolichyl-phosphate beta-D-mannosyltransferase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005537Mannose bindingIEAmolecular_function
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005789Endoplasmic reticulum membraneIDA TAScellular_component
GO:0006488Dolichol-linked oligosaccharide biosynthetic processTASbiological_process
GO:0006501C-terminal protein lipidationTASbiological_process
GO:0006506GPI anchor biosynthetic processIDAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016757Transferase activity, transferring glycosyl groupsIEAmolecular_function
GO:0018279Protein N-linked glycosylation via asparagineTASbiological_process
GO:0019348Dolichol metabolic processIDAbiological_process
GO:0019673GDP-mannose metabolic processIEAbiological_process
GO:0033185Dolichol-phosphate-mannose synthase complexIDAcellular_component
GO:0035268Protein mannosylationIDAbiological_process
GO:0035269Protein O-linked mannosylationIDAbiological_process
GO:0043178Alcohol bindingIEAmolecular_function
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19881477150.84472508260.86147360541.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0161859891
GSE13712_SHEARUp0.0614232637
GSE13712_STATICUp0.1468841010
GSE19018Down-0.0967346097
GSE19899_A1Up0.1846753881
GSE19899_A2Up0.1617629566
PubMed_21979375_A1Up0.5190058733
PubMed_21979375_A2Up0.4567548186
GSE35957Up0.0733946634
GSE36640Up0.1665918248
GSE54402Up0.2042709851
GSE9593Down-0.0194883653
GSE43922Down-0.0054371732
GSE24585Down-0.0268831835
GSE37065Up0.1119594885
GSE28863_A1Up0.2143186859
GSE28863_A2Up0.0492962458
GSE28863_A3Down-0.3860933136
GSE28863_A4Up0.3866624902
GSE48662Down-0.5876198084

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029861MicroarrayFunctional MTI (Weak)19088304
hsa-miR-18b-5pMIMAT0001412MIRT042406CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

10751218Human diploid fibroblasts (HDFs) underwent either 30 mean population doublings [mean population doublings (MPDs) thymidine labeling index (TI) >92% ("young") or between 53 and 58 MPDs (TI < 28%; "senescent")]
9535781We therefore measured cytosolic Ca2+ levels in 'young' (30 mean population doublings, MPDs) and 'senescent' (53 to 58 MPDs) human diploid fibroblasts (HDFs)
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