HCSGD entry for CCNK
1. General information
| Official gene symbol | CCNK |
|---|---|
| Entrez ID | 8812 |
| Gene full name | cyclin K |
| Other gene symbols | CPR4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000079 | Regulation of cyclin-dependent protein serine/threonine kinase activity | IEA | biological_process |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0002944 | Cyclin K-CDK12 complex | IPI | cellular_component |
| GO:0002945 | Cyclin K-CDK13 complex | IPI | cellular_component |
| GO:0004693 | Cyclin-dependent protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006468 | Protein phosphorylation | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IMP | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity | IDA | molecular_function |
| GO:0016310 | Phosphorylation | IDA | biological_process |
| GO:0019901 | Protein kinase binding | IEA IPI | molecular_function |
| GO:0071157 | Negative regulation of cell cycle arrest | IGI | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0950838988 | 0.9867693363 | 0.6456922859 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1340108551 |
| GSE13712_SHEAR | Up | 0.2300056230 |
| GSE13712_STATIC | Up | 0.1748677793 |
| GSE19018 | Down | -0.0047651147 |
| GSE19899_A1 | Up | 0.0384356352 |
| GSE19899_A2 | Up | 0.4637324701 |
| PubMed_21979375_A1 | Up | 0.2876504243 |
| PubMed_21979375_A2 | Up | 1.0260306530 |
| GSE35957 | Down | -0.0285657368 |
| GSE36640 | Down | -0.1673196203 |
| GSE54402 | Up | 0.1708990942 |
| GSE9593 | Up | 0.0578164497 |
| GSE43922 | Up | 0.0697555364 |
| GSE24585 | Up | 0.0477162439 |
| GSE37065 | Up | 0.0866378261 |
| GSE28863_A1 | Up | 0.0899243661 |
| GSE28863_A2 | Up | 0.1441524345 |
| GSE28863_A3 | Up | 0.1733929727 |
| GSE28863_A4 | Up | 0.1567373047 |
| GSE48662 | Up | 0.3165495081 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7b-5p | MIMAT0000063 | MIRT032200 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038452 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041776 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
