HCSGD entry for CCNK

1. General information

Official gene symbolCCNK
Entrez ID8812
Gene full namecyclin K
Other gene symbolsCPR4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000079Regulation of cyclin-dependent protein serine/threonine kinase activityIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002944Cyclin K-CDK12 complexIPIcellular_component
GO:0002945Cyclin K-CDK13 complexIPIcellular_component
GO:0004693Cyclin-dependent protein serine/threonine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIMPbiological_process
GO:0007067MitosisIEAbiological_process
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityIDAmolecular_function
GO:0016310PhosphorylationIDAbiological_process
GO:0019901Protein kinase bindingIEA IPImolecular_function
GO:0071157Negative regulation of cell cycle arrestIGIbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09508389880.98676933630.64569228591.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1340108551
GSE13712_SHEARUp0.2300056230
GSE13712_STATICUp0.1748677793
GSE19018Down-0.0047651147
GSE19899_A1Up0.0384356352
GSE19899_A2Up0.4637324701
PubMed_21979375_A1Up0.2876504243
PubMed_21979375_A2Up1.0260306530
GSE35957Down-0.0285657368
GSE36640Down-0.1673196203
GSE54402Up0.1708990942
GSE9593Up0.0578164497
GSE43922Up0.0697555364
GSE24585Up0.0477162439
GSE37065Up0.0866378261
GSE28863_A1Up0.0899243661
GSE28863_A2Up0.1441524345
GSE28863_A3Up0.1733929727
GSE28863_A4Up0.1567373047
GSE48662Up0.3165495081

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7b-5pMIMAT0000063MIRT032200ProteomicsFunctional MTI (Weak)18668040
hsa-miR-296-3pMIMAT0004679MIRT038452CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041776CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.