HCSGD entry for ADAM9

1. General information

Official gene symbolADAM9
Entrez ID8754
Gene full nameADAM metallopeptidase domain 9
Other gene symbolsCORD9 MCMP MDC9 Mltng
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000186Activation of MAPKK activityIDAbiological_process
GO:0004222Metalloendopeptidase activityIDA IEA IMPmolecular_function
GO:0005080Protein kinase C bindingISSmolecular_function
GO:0005178Integrin bindingIC IDA IPImolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005518Collagen bindingIMPmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005615Extracellular spaceIDA ISScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006509Membrane protein ectodomain proteolysisIDA IMPbiological_process
GO:0007155Cell adhesionIMPbiological_process
GO:0007160Cell-matrix adhesionIMPbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayIMP ISSbiological_process
GO:0007229Integrin-mediated signaling pathwayICbiological_process
GO:0008237Metallopeptidase activityIMPmolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009986Cell surfaceISScellular_component
GO:0010042Response to manganese ionIMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0017124SH3 domain bindingIPI ISSmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030216Keratinocyte differentiationIEPbiological_process
GO:0030574Collagen catabolic processTASbiological_process
GO:0031233Intrinsic component of external side of plasma membraneISScellular_component
GO:0033627Cell adhesion mediated by integrinIMPbiological_process
GO:0033630Positive regulation of cell adhesion mediated by integrinIMPbiological_process
GO:0033631Cell-cell adhesion mediated by integrinIEPbiological_process
GO:0034241Positive regulation of macrophage fusionIMPbiological_process
GO:0034612Response to tumor necrosis factorIDAbiological_process
GO:0034616Response to laminar fluid shear stressIEAbiological_process
GO:0042117Monocyte activationIMPbiological_process
GO:0042542Response to hydrogen peroxideIMPbiological_process
GO:0043236Laminin bindingIMPmolecular_function
GO:0050714Positive regulation of protein secretionIDAbiological_process
GO:0051044Positive regulation of membrane protein ectodomain proteolysisISSbiological_process
GO:0051088PMA-inducible membrane protein ectodomain proteolysisIDA TASbiological_process
GO:0051384Response to glucocorticoidISSbiological_process
GO:0051549Positive regulation of keratinocyte migrationIMPbiological_process
GO:0051592Response to calcium ionIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.24816641840.10687094340.93637697820.6257953504

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0166714243
GSE13712_SHEARUp0.8194691918
GSE13712_STATICUp0.6877874723
GSE19018Up0.2355729158
GSE19899_A1Down-0.5708456243
GSE19899_A2Down-0.3780291603
PubMed_21979375_A1Down-0.8141389300
PubMed_21979375_A2Down-0.4920197661
GSE35957Up0.0382033039
GSE36640Up0.0310697911
GSE54402Down-0.5829354083
GSE9593Up0.5300191166
GSE43922Down-0.4063080971
GSE24585Down-0.1712297281
GSE37065Down-0.2249315827
GSE28863_A1Up0.4286757535
GSE28863_A2Up0.7657796580
GSE28863_A3Down-0.2016806754
GSE28863_A4Down-0.0487450618
GSE48662Down-0.1889941075

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

INCB7839DB05033 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-373-3pMIMAT0000726MIRT002555Microarray//Microarray;OtherFunctional MTI (Weak)15685193
hsa-miR-126-3pMIMAT0000445MIRT007266Luciferase reporter assayFunctional MTI23437250
hsa-miR-126-5pMIMAT0000444MIRT007267Luciferase reporter assayFunctional MTI23437250
hsa-miR-26b-5pMIMAT0000083MIRT030283MicroarrayFunctional MTI (Weak)19088304
hsa-miR-23a-3pMIMAT0000078MIRT050441CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-373-3pMIMAT0000726NAhsa-miR-37315685193
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.