HCSGD entry for ADAM9
1. General information
| Official gene symbol | ADAM9 |
|---|---|
| Entrez ID | 8754 |
| Gene full name | ADAM metallopeptidase domain 9 |
| Other gene symbols | CORD9 MCMP MDC9 Mltng |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000186 | Activation of MAPKK activity | IDA | biological_process |
| GO:0004222 | Metalloendopeptidase activity | IDA IEA IMP | molecular_function |
| GO:0005080 | Protein kinase C binding | ISS | molecular_function |
| GO:0005178 | Integrin binding | IC IDA IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005518 | Collagen binding | IMP | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005615 | Extracellular space | IDA ISS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0006509 | Membrane protein ectodomain proteolysis | IDA IMP | biological_process |
| GO:0007155 | Cell adhesion | IMP | biological_process |
| GO:0007160 | Cell-matrix adhesion | IMP | biological_process |
| GO:0007179 | Transforming growth factor beta receptor signaling pathway | IMP ISS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IC | biological_process |
| GO:0008237 | Metallopeptidase activity | IMP | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009986 | Cell surface | ISS | cellular_component |
| GO:0010042 | Response to manganese ion | IMP | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0016323 | Basolateral plasma membrane | IEA | cellular_component |
| GO:0017124 | SH3 domain binding | IPI ISS | molecular_function |
| GO:0022617 | Extracellular matrix disassembly | TAS | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0030216 | Keratinocyte differentiation | IEP | biological_process |
| GO:0030574 | Collagen catabolic process | TAS | biological_process |
| GO:0031233 | Intrinsic component of external side of plasma membrane | ISS | cellular_component |
| GO:0033627 | Cell adhesion mediated by integrin | IMP | biological_process |
| GO:0033630 | Positive regulation of cell adhesion mediated by integrin | IMP | biological_process |
| GO:0033631 | Cell-cell adhesion mediated by integrin | IEP | biological_process |
| GO:0034241 | Positive regulation of macrophage fusion | IMP | biological_process |
| GO:0034612 | Response to tumor necrosis factor | IDA | biological_process |
| GO:0034616 | Response to laminar fluid shear stress | IEA | biological_process |
| GO:0042117 | Monocyte activation | IMP | biological_process |
| GO:0042542 | Response to hydrogen peroxide | IMP | biological_process |
| GO:0043236 | Laminin binding | IMP | molecular_function |
| GO:0050714 | Positive regulation of protein secretion | IDA | biological_process |
| GO:0051044 | Positive regulation of membrane protein ectodomain proteolysis | ISS | biological_process |
| GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis | IDA TAS | biological_process |
| GO:0051384 | Response to glucocorticoid | ISS | biological_process |
| GO:0051549 | Positive regulation of keratinocyte migration | IMP | biological_process |
| GO:0051592 | Response to calcium ion | IMP | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2481664184 | 0.1068709434 | 0.9363769782 | 0.6257953504 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0166714243 |
| GSE13712_SHEAR | Up | 0.8194691918 |
| GSE13712_STATIC | Up | 0.6877874723 |
| GSE19018 | Up | 0.2355729158 |
| GSE19899_A1 | Down | -0.5708456243 |
| GSE19899_A2 | Down | -0.3780291603 |
| PubMed_21979375_A1 | Down | -0.8141389300 |
| PubMed_21979375_A2 | Down | -0.4920197661 |
| GSE35957 | Up | 0.0382033039 |
| GSE36640 | Up | 0.0310697911 |
| GSE54402 | Down | -0.5829354083 |
| GSE9593 | Up | 0.5300191166 |
| GSE43922 | Down | -0.4063080971 |
| GSE24585 | Down | -0.1712297281 |
| GSE37065 | Down | -0.2249315827 |
| GSE28863_A1 | Up | 0.4286757535 |
| GSE28863_A2 | Up | 0.7657796580 |
| GSE28863_A3 | Down | -0.2016806754 |
| GSE28863_A4 | Down | -0.0487450618 |
| GSE48662 | Down | -0.1889941075 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| INCB7839 | DB05033 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | MIRT002555 | Microarray//Microarray;Other | Functional MTI (Weak) | 15685193 |
| hsa-miR-126-3p | MIMAT0000445 | MIRT007266 | Luciferase reporter assay | Functional MTI | 23437250 |
| hsa-miR-126-5p | MIMAT0000444 | MIRT007267 | Luciferase reporter assay | Functional MTI | 23437250 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030283 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-23a-3p | MIMAT0000078 | MIRT050441 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-373-3p | MIMAT0000726 | NA | hsa-miR-373 | 15685193 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
