HCSGD entry for TNKS
1. General information
| Official gene symbol | TNKS |
|---|---|
| Entrez ID | 8658 |
| Gene full name | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase |
| Other gene symbols | ARTD5 PARP-5a PARP5A PARPL TIN1 TINF1 TNKS1 pART5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0000209 | Protein polyubiquitination | IDA | biological_process |
| GO:0000242 | Pericentriolar material | TAS | cellular_component |
| GO:0000775 | Chromosome, centromeric region | IEA | cellular_component |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0000784 | Nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006471 | Protein ADP-ribosylation | IDA | biological_process |
| GO:0007052 | Mitotic spindle organization | TAS | biological_process |
| GO:0007067 | Mitosis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IDA | molecular_function |
| GO:0015031 | Protein transport | IEA | biological_process |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0018107 | Peptidyl-threonine phosphorylation | IDA | biological_process |
| GO:0031965 | Nuclear membrane | TAS | cellular_component |
| GO:0032210 | Regulation of telomere maintenance via telomerase | IC | biological_process |
| GO:0032212 | Positive regulation of telomere maintenance via telomerase | IDA IMP | biological_process |
| GO:0043392 | Negative regulation of DNA binding | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0051028 | MRNA transport | IEA | biological_process |
| GO:0051225 | Spindle assembly | TAS | biological_process |
| GO:0070198 | Protein localization to chromosome, telomeric region | IMP | biological_process |
| GO:0070212 | Protein poly-ADP-ribosylation | IDA | biological_process |
| GO:0070213 | Protein auto-ADP-ribosylation | IDA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5764836784 | 0.3565739258 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0140281737 |
| GSE13712_SHEAR | Down | -0.0932371159 |
| GSE13712_STATIC | Down | -0.0185058475 |
| GSE19018 | Up | 0.1434119335 |
| GSE19899_A1 | Down | -0.0113368993 |
| GSE19899_A2 | Down | -0.2550437482 |
| PubMed_21979375_A1 | Down | -0.3451347269 |
| PubMed_21979375_A2 | Down | -0.1809823366 |
| GSE35957 | Up | 0.0445722821 |
| GSE36640 | Down | -0.0015613275 |
| GSE54402 | Down | -0.0350140514 |
| GSE9593 | Up | 0.1331189825 |
| GSE43922 | Down | -0.0656538991 |
| GSE24585 | Up | 0.1991488224 |
| GSE37065 | Up | 0.0704975686 |
| GSE28863_A1 | Up | 0.6840469411 |
| GSE28863_A2 | Up | 0.7594134343 |
| GSE28863_A3 | Down | -0.5104250860 |
| GSE28863_A4 | Down | -0.3484798678 |
| GSE48662 | Down | -0.1281221870 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028854 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037431 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT043012 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043016 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25190315 | Telomeres, telomerase and tankyrase (TNKS) have an extremely important and special association with human cell aging and cancer |
| 25190315 | Telomerase activity is abnormally high in cancer cells and is accompanied by the overexpression of tankyrase 1 (TNKS1) |
| 25190315 | TNKS1 is a positive regulator of telomerase activation and telomere extension in the human body, indicating that TNKS1 may be a possible therapeutic target for cancer |
| 25190315 | XAV939 is a small-molecule inhibitor of TNKS1 |
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