HCSGD entry for TNKS

1. General information

Official gene symbolTNKS
Entrez ID8658
Gene full nametankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Other gene symbolsARTD5 PARP-5a PARP5A PARPL TIN1 TINF1 TNKS1 pART5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000139Golgi membraneIEAcellular_component
GO:0000209Protein polyubiquitinationIDAbiological_process
GO:0000242Pericentriolar materialTAScellular_component
GO:0000775Chromosome, centromeric regionIEAcellular_component
GO:0000781Chromosome, telomeric regionIDAcellular_component
GO:0000784Nuclear chromosome, telomeric regionIDAcellular_component
GO:0000922Spindle poleIEAcellular_component
GO:0003950NAD+ ADP-ribosyltransferase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005643Nuclear poreTAScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0006471Protein ADP-ribosylationIDAbiological_process
GO:0007052Mitotic spindle organizationTASbiological_process
GO:0007067MitosisIEAbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0015031Protein transportIEAbiological_process
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0018105Peptidyl-serine phosphorylationIDAbiological_process
GO:0018107Peptidyl-threonine phosphorylationIDAbiological_process
GO:0031965Nuclear membraneTAScellular_component
GO:0032210Regulation of telomere maintenance via telomeraseICbiological_process
GO:0032212Positive regulation of telomere maintenance via telomeraseIDA IMPbiological_process
GO:0043392Negative regulation of DNA bindingIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0051028MRNA transportIEAbiological_process
GO:0051225Spindle assemblyTASbiological_process
GO:0070198Protein localization to chromosome, telomeric regionIMPbiological_process
GO:0070212Protein poly-ADP-ribosylationIDAbiological_process
GO:0070213Protein auto-ADP-ribosylationIDAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57648367840.35657392580.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0140281737
GSE13712_SHEARDown-0.0932371159
GSE13712_STATICDown-0.0185058475
GSE19018Up0.1434119335
GSE19899_A1Down-0.0113368993
GSE19899_A2Down-0.2550437482
PubMed_21979375_A1Down-0.3451347269
PubMed_21979375_A2Down-0.1809823366
GSE35957Up0.0445722821
GSE36640Down-0.0015613275
GSE54402Down-0.0350140514
GSE9593Up0.1331189825
GSE43922Down-0.0656538991
GSE24585Up0.1991488224
GSE37065Up0.0704975686
GSE28863_A1Up0.6840469411
GSE28863_A2Up0.7594134343
GSE28863_A3Down-0.5104250860
GSE28863_A4Down-0.3484798678
GSE48662Down-0.1281221870

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT028854MicroarrayFunctional MTI (Weak)19088304
hsa-miR-744-5pMIMAT0004945MIRT037431CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT043012CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043016CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25190315Telomeres, telomerase and tankyrase (TNKS) have an extremely important and special association with human cell aging and cancer
25190315Telomerase activity is abnormally high in cancer cells and is accompanied by the overexpression of tankyrase 1 (TNKS1)
25190315TNKS1 is a positive regulator of telomerase activation and telomere extension in the human body, indicating that TNKS1 may be a possible therapeutic target for cancer
25190315XAV939 is a small-molecule inhibitor of TNKS1
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