HCSGD entry for CASK

1. General information

Official gene symbolCASK
Entrez ID8573
Gene full namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Other gene symbolsCAGH39 CAMGUK CMG FGS4 LIN2 MICPCH MRXSNA TNRC8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001953Negative regulation of cell-matrix adhesionIMPbiological_process
GO:0004385Guanylate kinase activityTASmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005604Basement membraneIDAcellular_component
GO:0005652Nuclear laminaIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007155Cell adhesionTASbiological_process
GO:0010839Negative regulation of keratinocyte proliferationIMPbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016363Nuclear matrixIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0042043Neurexin family protein bindingIEAmolecular_function
GO:0042734Presynaptic membraneISScellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046939Nucleotide phosphorylationTASbiological_process
GO:0060170Ciliary membraneISScellular_component
GO:0061045Negative regulation of wound healingIMPbiological_process
GO:0070509Calcium ion importIEAbiological_process
GO:0090280Positive regulation of calcium ion importIEAbiological_process
GO:0090288Negative regulation of cellular response to growth factor stimulusIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57918617450.15946595110.99999024730.7712795480

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1734007294
GSE13712_SHEARDown-1.0690790070
GSE13712_STATICDown-0.3255715425
GSE19018Down-0.1667709755
GSE19899_A1Down-0.1624963977
GSE19899_A2Down-0.3888306630
PubMed_21979375_A1Up0.7140162729
PubMed_21979375_A2Down-0.0252445863
GSE35957Down-0.3409187751
GSE36640Up0.6337835316
GSE54402Up0.1137551664
GSE9593Up0.2150040934
GSE43922Down-0.1607063788
GSE24585Down-0.6154056084
GSE37065Up0.1582603374
GSE28863_A1Up0.0767185275
GSE28863_A2Up0.4910497117
GSE28863_A3Down-0.2579264371
GSE28863_A4Up0.0226643756
GSE48662Up0.0196528099

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Formic AcidDB01942 EXPT01461

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031989ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.