HCSGD entry for CASK


1. General information

Official gene symbolCASK
Entrez ID8573
Gene full namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Other gene symbolsCAGH39 CAMGUK CMG FGS4 LIN2 MICPCH MRXSNA TNRC8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001953Negative regulation of cell-matrix adhesionIMPbiological_process
GO:0004385Guanylate kinase activityTASmolecular_function
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005604Basement membraneIDAcellular_component
GO:0005652Nuclear laminaIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007155Cell adhesionTASbiological_process
GO:0010839Negative regulation of keratinocyte proliferationIMPbiological_process
GO:0015629Actin cytoskeletonTAScellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0016363Nuclear matrixIDAcellular_component
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0042043Neurexin family protein bindingIEAmolecular_function
GO:0042734Presynaptic membraneISScellular_component
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0046939Nucleotide phosphorylationTASbiological_process
GO:0060170Ciliary membraneISScellular_component
GO:0061045Negative regulation of wound healingIMPbiological_process
GO:0070509Calcium ion importIEAbiological_process
GO:0090280Positive regulation of calcium ion importIEAbiological_process
GO:0090288Negative regulation of cellular response to growth factor stimulusIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.57918617450.15946595110.99999024730.7712795480

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1734007294
GSE13712_SHEARDown-1.0690790070
GSE13712_STATICDown-0.3255715425
GSE19018Down-0.1667709755
GSE19899_A1Down-0.1624963977
GSE19899_A2Down-0.3888306630
PubMed_21979375_A1Up0.7140162729
PubMed_21979375_A2Down-0.0252445863
GSE35957Down-0.3409187751
GSE36640Up0.6337835316
GSE54402Up0.1137551664
GSE9593Up0.2150040934
GSE43922Down-0.1607063788
GSE24585Down-0.6154056084
GSE37065Up0.1582603374
GSE28863_A1Up0.0767185275
GSE28863_A2Up0.4910497117
GSE28863_A3Down-0.2579264371
GSE28863_A4Up0.0226643756
GSE48662Up0.0196528099

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Formic AcidDB01942 EXPT01461

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031989ProteomicsFunctional MTI (Weak)18668040
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.