HCSGD entry for MADD

1. General information

Official gene symbolMADD
Entrez ID8567
Gene full nameMAP-kinase activating death domain
Other gene symbolsDENN IG20 RAB3GEP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIMPbiological_process
GO:0005123Death receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0017112Rab guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0030295Protein kinase activator activityTASmolecular_function
GO:0032313Regulation of Rab GTPase activityIDA IMPbiological_process
GO:0032318Regulation of Ras GTPase activityIDA IMPbiological_process
GO:0032483Regulation of Rab protein signal transductionIDAbiological_process
GO:0042981Regulation of apoptotic processIMPbiological_process
GO:0043087Regulation of GTPase activityIDA IMPbiological_process
GO:0051726Regulation of cell cycleIMPbiological_process
GO:0097194Execution phase of apoptosisIMPbiological_process
GO:1902041Regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
GO:2001236Regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07490383720.94726251280.57986585291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0336380170
GSE13712_SHEARUp0.0246777374
GSE13712_STATICDown-0.0698045900
GSE19018Up0.0551071101
GSE19899_A1Up0.0974963626
GSE19899_A2Up0.1968076337
PubMed_21979375_A1Up1.1287153642
PubMed_21979375_A2Up0.3888041145
GSE35957Down-0.0826681204
GSE36640Up0.0251591918
GSE54402Up0.3154076709
GSE9593Down-0.2396750590
GSE43922Up0.1830562800
GSE24585Up0.4310893137
GSE37065Up0.0963581089
GSE28863_A1Up0.3352850097
GSE28863_A2Up0.6057008860
GSE28863_A3Down-0.2808044379
GSE28863_A4Down-0.1276519048
GSE48662Up0.2302523354

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029280MicroarrayFunctional MTI (Weak)19088304
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.